Research Article

Area under the Curve-Based Dosing of Vancomycin in Critically Ill Patients Using 6-Hour Urine Creatinine Clearance Measurement

Table 2

Appropriate total daily dose of vancomycin in various ranges of CL6 h to achieve target AUC24 h of 400 or 600 mg·hr/L considering IBW equal to 70 kg.

CL6 h (mL/min)A total daily dose of vancomycin (mg) to achieve target AUC24 h
Target AUC24 h of 400 (mg·hr/L)Target AUC24 h of 600 (mg·hr/L)

6022503500
8027504000
10032504750
1203750

Target AUC24 h of 400 mg.hr/L may be considered because of the total daily dose >4 g. Abbreviations: CL6 h: measured creatinine clearance in 6-hour urine collection; AUC24 h: 24-hour area under the curve.