Review Article

The Use of CytoSorb Therapy in Critically Ill COVID-19 Patients: Review of the Rationale and Current Clinical Experiences

Table 1

Overview of the currently available literature.

AuthorStudy title detailsType of studyCountryNumber of patientsImprovement in hemodynamicsImprovement in oxygenationControl of inflammatory responseReference number from manuscript

Alharthy AContinuous Renal Replacement Therapy with the Addition of CytoSorb® Cartridge in Critically Ill Patients with COVID‐19 plus Acute Kidney Injury: a Case‐Series. Artificial Organs 2021; 45(5):E101-112Retrospective case seriesSaudi Arabia50YesYes31
Berlot GEffects of Tocilizumab Versus Hemoadsorption Combined with Tocilizumab in Patients with SARS-CoV-2 Pneumonia: Preliminary Results. Int J Artif organs 2021; epubRetrospective case seriesItaly2YesYes51
Rieder M et al.Cytokine Adsorption in Patients with Severe COVID-19 Pneumonia Requiring Extracorporeal Membrane Oxygenation. Crit Care 2020; 24: 435Randomized control trial—Interim analysisGermany4 vs 4Yes55
Rampino T et al.Hemoperfusion with CytoSorb as Adjuvant Therapy in Critically Ill Patients with SARS-CoV2 Pneumonia. Blood Purif 2020; epubRetrospective case seriesItaly5 of 9 consecutive pts treated with CytoSorbYesYes56
Lebreton G et al.Longitudinal Cytokine Profiling in Severe COVID-19 Patients on ECMO and Hemoadsorption. AJRCCM 2021; 203(11): 1433–5Prospective case seriesFrance11 consecutive patients on CytoSorb compared to 11 noncontemporaneous ptsYes57
Ferrer RRegain control of Inflammation – IL6 Blockers or CytoSorb (or both)? Presented at “the trinity of COVID-19: Immunity, Inflammation and Intervention Webinar,” May 20th 2020.Webinar presentation of retrospective patientsSpain7YesYes59
Moazami NCytoSorb: First Clinical Experience in the USA. Presented at the “EuroELSO Virtual ECMO Day,” June 25th 2020Webinar presentation of retrospective patientsUSA10 vs 10YesYes65
Nassiri AABlood Purification with CytoSorb in Critically Ill COVID-19 Patients: A Case Series of 26 Patients. Artif Org 2021; epubRetrospective case seriesIran26YesYesYes66
Peng ZSafety and Feasibility of CytoSorb Therapy in COVID-19 Patients–the Wuhan Experience. Presented at the “Cytokine Adsorption in Severely Ill COVID-19 Patients” Webinar. April 16th 2020.Webinar presentation of retrospective patientsChina10YesYesYes69
Nierhaus ARationale for the Use of CytoSorb in COVID-19 Patients. Presented at the “7th International CytoSorb Users’ Meeting” Webinar. 29th Oct 2020Webinar presentation of preliminary RCT resultsGermany5 vs 5YesYes70
Lopez-Almarez JCytoSorb Therapy in COVID-19 Patients. Experiences from Latin America. Presented at the “7th International CytoSorb Users’ Meeting” Webinar. 29th Oct 2020Webinar presentation of retrospective patientsLatin America25YesYesYes71
Riva IIts More than Cytokine Removal, Presented at the “Cytokine Adsorption in Severely Ill COVID-19 Patients”Webinar presentation of retrospective patientsItaly11 vs 10YesYes68