Does Early Graft Patency Benefit from Perioperative Statin Therapy? A Propensity Score-Matched Study of Patients Undergoing Off-Pump Coronary Artery Bypass Surgery

Table 5

Secondary outcomes: effect on liver function and clinical outcomes at discharge.

Secondary outcomes	Before IPW Adjustment			After IPW Adjustment
	CS group; (n=398)	DS group; (n=184)	P-Value	CS group	DS group	P-Value
LDL-C, mg/dL	65.35	76.57	0.038	65.02	78.56	<0.001
TC, mmol/L	3.33	3.56	<0.001	3.32	3.63	<0.001
Creatinine, mg/dL	1.04	1.05	NS	1.04	1.06	NS
GFR, mL/min/1.73m^2 †	75.53	77.46	NS	76.28	76.13	NS
ALT, U/L	48.51	36.56	0.001	49.67	34.52	<0.001
AST, U/L	33.20	27.97	0.017	33.54	28.10	<0.001
Abnormal ALT, % (n) ‡	8.5 (34)	3.8 (7)	0.038	8.9	3.1	<0.001
Abnormal AST, % (n) ‡	1.3 (5)	1.1 (2)	NS	1.2	1.0	NS
Intraoperative blood loss, mL	432.46	521.23	0.001	438.53	480.47	0.010

LDL-C = low-density lipoprotein cholesterol; TC = total cholesterol; GFR = glomerular filtration rate; ALT = alanine transaminase; AST = aspartate aminotransferase.
†The glomerular filtration rate (GFR) was estimated with the Chronic Kidney Disease Epidemiology Collaboration (CKD-EPI) equation.
‡Abnormal ALT (or AST) was defined as ALT (or AST) >3×upper limit of normal (ULN).