Both CYP2C19 and PON1 Q192R Genotypes Influence Platelet Response to Clopidogrel by Thrombelastography in Patients with Acute Coronary Syndrome

Table 3

Relationship between genotypes and platelet inhibition.

Variant genotype SNP		NPR; (n=275)	HPR; (n=184)	Odds Ratio(95%CI)	P value	Adjusted Odds Ratio(95%CI)	P value
CYP2C192	GA(1/2)	97(35.3%)	83(45.1%)	1.508(1.030,2.208)	0.034	1.607(1.087,2.378)	0.018
	AA(2/2)	29(10.5%)	22(12.0%)	1.152(0.639,2.075)	0.637	1.090(0.807,1.471)	0.575
	At least 1	126(45.8%)	105(57.1%)	1.572(1.079,2.289)	0.018	1.696(1.151,2.498)	0.008
CYP2C193	GA(1/3)	21(7.6%)	22(12.0%)	1.643(0.875,3.083)	0.120	1.483(1.125,1.956)	0.005
	AA(3/3)	0	0	-	-	-	-
	At least 1	21(7.6%)	22(12.0%)	1.643(0.875,3.083)	0.120	1.483(1.125,1.956)	0.005
CYP2C19 LOF allele number	1	108(39.3%)	89(48.4%)	1.449(0.994,2.112)	0.054	1.525(1.036,2.245)	0.032
	2	34(12.4%)	30(16.3%)	1.381(0.812,2.348)	0.232	1.430(0.832,2.459)	0.195
	At least 1	142(51.6%)	119(64.8%)	1.715(1.168,2.517)	0.006	1.846(1.243,2.741)	0.002
CYP2C1917	CT(1/17)	7(2.5%)	4(2.2%)	0.851(0.245,2.949)	0.799	0.896(0.253,3.174)	0.865
	TT(17/17)	0	1(0.5%)	-	-	-	-
	At least 1	7(2.5%)	5(2.7%)	1.069(0.334,3.422)	0.910	1.153(0.353,3.763)	0.813
PON1	QR(AG)	126(45.8%)	95(51.6%)	1.262(0.868,1.835)	0.222	1.304(0.889,1.911)	0.174
	RR(GG)	103(37.5%)	72(39.1%)	1.074(0.731,1.576)	0.717	1.053(0.711,1.558)	0.798
	At least 1R	229(83.3%)	167(90.8%)	1.973(1.093,3.563)	0.022	2.033(1.112,3.718)	0.021
ABCB1	CT	137(49.8%)	90(48.9%)	0.964(0.664,1.401)	0.849	0.971(0.663,1.421)	0.878
	TT	36(13.1%)	28(15.2%)	1.192(0.699,2.031)	0.519	1.273(0.738,2.193)	0.386
	At least 1T	173(62.9%)	118(64.1%)	1.054(0.715,1.554)	0.790	1.099(0.739,1.634)	0.642

Adjusted risk factor of gender by logistic regression model.