Safety and Tolerability of Initiating Maximum-Dose Sacubitril-Valsartan in Patients on Target Dose Renin-Angiotensin System Inhibitors

Table 2

Reasons for discontinuation of sacubitril-valsartan within first year.

Number	Patient	Reason for discontinuation
1	87-year-old man	Dizziness, syncope, and a slowly developing itching rash
2	82-year-old woman	Irritated bowels
3	81-year-old man	Slowly developing itching rash
4	80-year-old man	Progressive kidney failure
5	79-year-old man	Orthostatic hypotension, even after dose reduction
6	76-year-old man	Coughing
7	77-year-old man	Progressive kidney failure
8	76-year-old man	Slowly developing itching rash
9	69-year-old man	Decided he did not want to continue with medication that is not currently endorsed by national guidelines