Cardiovascular Therapeutics / 2019 / Article / Tab 2

Review Article

Combating Donor Organ Shortage: Organ Care System Prolonging Organ Storage Time and Improving the Outcome of Heart Transplantations

Table 2

Study Results.

Study Results
StudiesCold Ischemic Time (min)OCS Perfusion Time (min)Total Time (min)Length of Hospital Stay30-day survival (%)Comments

Saez et al. [7]85 ±17284 ± 92371 ± 10239 ± 29 days100%(i) Cardiac function preserved in 92% of patients
(ii) Mean duration on inotropic support – 113 ± 85 hours
(iii) Length of ICU stay – 6 days
(iv) Longest period of OCS support - 464 minutes

Koerner et al. [8]-26 days96%(i) 30-day survival rate (OCS: 96%; CS: 95%)
(ii) 1-year survival rate (OCS: 89%; CS: 81%)
(iii) 2-year survival rate (OCS: 89%; CS: 79%)
(iv) Lower primary graft failure (OCS: 6.89%; CS: 15.3%)
(v) Lower episodes of rejection (OCS: 17.2%; CS: 23%)
(vi) Lower cases of acute renal failure (OCS: 10%; CS: 25.3%)
(vii) No difference in hospital stay (OCS: 26 days; CS: 28 days)

Yeter et al. [9]68320388-95%(i) Survival rate of 95% at 30 days and 6 months and 87% at one year and four years, respectively.
(ii) No post-transplant vasculopathy incidences were reported

Saez et al. [10]240--(i) 4 hearts were able to resuscitated
(ii) 3 were transplantable with excellent visual contractility and lactate trends
(iii) One was found unsuitable for transplantation with abnormal lactate levels and impaired contractility

Iyer et al. [11]90240330--OCS Hearts
(i) All OCS hearts are able to be weaned off cardiopulmonary bypass (CBG) and support the animal’s circulation with the use of inotropic support
(ii) Stable hemodynamics 3 hours post weaning
Cold Storage (CS)
(i) None of the 3 hearts in the CS group could be weaned from CPB, despite escalation of inotrope doses.
(ii) Unable to establish stable cardiac rhythm
(iii) Poor contractility

Saez et al. [12]89 ± 17312373 ± 9537.5 days73.3%(i) Cold Storage: Cold Ischemic Time (204 ± 29 min)
(ii) 30-day survival rate (OCS: 73.3%, CS: 100%)
(iii) Blood loss within 24h (OCS 900 mL, CS 1475 mL)
(iv) Duration of inotropic support (OCS 96 hours, CS 204 hours)
(v) Length of ICU stay (OCS 7 days, CS 25 days)

Ardehali et al. [13]113211324-94%(i) Cold Storage: Cold & Total Ischemic Time (195 min) 30-day survival rate (97%)
(ii) No significant difference in MACE, rejection rates and length of ICU stay in OCS and CS group respectively (13 vs 14%; 18 vs 14%; 147 days vs 137 days)

Stamp et al. [14]10550361115100%No episodes of rejection 1-year post transplant.

Dhital et al. [15]25 ± 3257 ± 1223291-176 days100% successful DCD heart transplant in a human

Chan et al. [16]134 ± 45-361 ± 96--(i) Cold storage: Cold & total ischemic time - 207 ± 50 min
(ii) No difference in 2-year patient survival rate (OCS: 72.2%; cold storage: 81.6%; p = 0.38)
(iii) Allograft rejection (OCS: 53%; cold storage: 61.8%)
(iv) No difference in MACE and vasculopathy incidences

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