Bazedoxifene Plays a Protective Role against Inflammatory Injury of Endothelial Cells by Targeting CD40

<div>Effect of CD40 on inflammation in VECs. VECs were transfected with siRNA targeting CD40. (a) The CD40 expression after transfection with siRNA targeting CD40. (b) The effect of CD40 on the migration of VECs. (c) The viability of VECs after transfection with siRNA targeting CD40. (d) The adhesion between THP-1 and VECs. Scale bar: 200 <i>μ</i>m. (e) ROS production after knocking down CD40. Scale bar: 100 <i>μ</i>m. (f) Mechanism, by which bazedoxifene improves TNF-<i>α</i>-induced endometrial dysfunction. 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Cardiovascular Therapeutics

fig4

Figure 4

Figure 4: Bazedoxifene Plays a Protective Role against Inflammatory Injury of Endothelial Cells by Targeting CD40 