Cardiovascular Therapeutics / 2020 / Article / Tab 1

Research Article

Identification of Target Genes of Antiarrhythmic Traditional Chinese Medicine Wenxin Keli

Table 1

Arrhythmia-related targets of active ingredients of WXKL.

CompoundOBDLTarget gene

Acacetin34.970.24ADRB2
Cryptotanshinone52.340.4ADRB2/SCN5A/ADRA1D
Stigmasterol43.830.76ADRB2/ADRB1/SCN5A/CHRM2/ADRA2A
Quercetin46.430.28ADRB2/GJA1
Sitogluside20.630.62ADRB2/ADRB1/KCNH2/SCN5A/ADRA1D
β-Sitosterol36.910.75ADRB2/KCNH2/SCN5A/CHRM2
Diop43.590.39ADRB2/SCN5A
Frutinone A65.90.34ADRB2/SCN5A
Compound 132.160.41ADRB2
DFV32.760.18ADRB2
Compound 271.120.18KCNH2

Compound 1: 3-beta-hydroxymethylenetanshiquinone. Compound 2: (2R)-7-hydroxy-2-(4-hydroxyphenyl)chroman-4-one.

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