Long Noncoding RNA HOTAIR Functions as a Competitive Endogenous RNA to Regulate Connexin43 Remodeling in Atrial Fibrillation by Sponging MicroRNA-613
Downregulation of Cx43 and HOTAIR in RAA of patients with chronic AF. (a) The expression of HOTAIR in RAA of patients with SR or chronic AF. (b) The expression of miR-613 in RAA of patients with SR or chronic AF. (c) The mRNA expression of Cx43 in RAA of patients with SR or chronic AF. (d) Western blot analysis and quantification of Cx43 between the two groups. GAPDH was used as an internal control. (e) Representative images of immunohistochemistry staining of Cx43 (×100) between the two groups. Brown staining represents Cx43. The Cx43 was marked with single arrow. , against the SR group. SR: sinus rhythm; AF: atrial fibrillation; RAA: right atrial appendage; miR: microRNA; HOTAIR: HOX transcript antisense RNA; Cx: connexin; GAPDH: glyceraldehyde-3-phosphate dehydrogenase. The error bars mean standard deviation.
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