Inherited Cardiac Arrhythmia Syndromes: Focus on Molecular Mechanisms Underlying TRPM4 Channelopathies

Figure 1

Overall structure of human full-length TRPM4 in the apo state. (a, b) Side and top views of the cryo-EM reconstruction density map of human TRPM4 at 3.7 Å overall resolution. (c, d) Ribbon diagrams representing the same orientation and colors with the channel’s dimensions indicated. (e) Structural details of a single human TRPM4 subunit. (f) Linear diagram depicting the major structural domains, color coded to match the ribbon diagram. The N-linked N992 glycosylation site (N-G) and the Cys993-Cys1011 disulfide bond are indicated; reprinted from [2].