Relationship between White Blood Count to Mean Platelet Volume Ratio and Clinical Outcomes and Severity of Coronary Artery Disease in Patients Undergoing Primary Percutaneous Coronary Intervention
Table 4
(a) Univariate and multivariate logistic regression analysis for determining the factors associated with in-hospital MACE
Variables
Univariate analysis
Multivariate analysis Model 1 (with GRACE)
Multivariate analysis Model 2 (with GRACE and WMR)
OR(95% CI)
OR(95% CI)
OR(95% CI)
Age
1.032(1.016-1.047)
<0.001
0.956(0.927-1.067)
0.103
0.960(0.930-1.017)
0.116
Male gender
0.852(0.544-1.333)
0.483
—
—
—
—
HT
1.584(1.065-2.356)
0.023
1.002(0.56-1.793)
0.993
0.996(0.556-1.785)
0.989
DM
1.79(1.226-2.613)
0.003
0.854(0.438-1.665)
0.644
0.847(0.434-1.653)
0.626
HL
1.571(1.058-2.332)
0.025
1.463(0.83-2.581)
0.189
1.493(0.844-2.642)
0.168
CAD
1.804(1.178-2.761)
0.007
1.275(0.699-2.326)
0.428
1.339(0.73-2.454)
0.345
Smoking
1.11(0.759-1.623)
0.590
—
—
—
—
Hba1c
1.284(1.156-1.426)
<0.001
1.129(0.937-1.361)
0.203
1.14(0.945-1.377)
0.171
CreCl (ml/min)
0.968(0.96-0.977)
<0.001
0.992(0.978-1.007)
0.295
0.995(0.98-1.009)
0.477
HB
0.85(0.772-0.936)
0.001
0.974(0.847-1.121)
0.715
0.947(0.821-1.092)
0.456
1.156(1.099-1.215)
<0.001
—
—
—
—
MPV
1.024(0.894-1.171)
0.736
—
—
—
—
WMR
2.805(1.752-4.488)
<0.001
—
—
1.764(1.046-2.976)
0.033
PLT
1.001(0.999-1.003)
0.331
—
—
—
—
LVEF
0.889(0.869-0.908)
<0.001
0.923(0.9-0.946)
<0.001
0.925(0.902-0.948)
<0.001
GRACE
1.045(1.036-1.054)
<0.001
1.043(1.027-1.059)
<0.001
1.042(1.026-1.058)
<0.001
RSS
1.145(1.112-1.179)
<0.001
1.070(1.033-1.107)
<0.001
1.067(1.03-1.105)
<0.001
C-Statistic (95% CI)
—
—
0.790(0.741-0.839)
<0.001
0.820(0.772-0.869)
<0.001
Hosmer-Lemeshow
—
—
5.143
0.424
8.102
0.742
(b) Univariate and multivariate Cox regression analysis for determining the risk factors associated with follow-up MACE
Variables
Univariate analysis
Multivariate analysis
HR(95% CI)
HR(95% CI)
Age
1.039(1.021-1.057)
<0.001
1.017(0.993-1.041)
0.160
Male gender
0.683(0.438-1.066)
0.093
—
—
HT
1.098(0.716-1.685)
0.668
—
—
DM
1.659(1.1-2.501)
0.016
0.967(0.556-1.684)
0.906
HL
0.979(0.642-1.493)
0.921
—
—
CAD
1.32(0.84-2.075)
0.229
—
—
Smoking
0.56(0.363-0.862)
0.009
0.752(0.464-1.217)
0.245
Hba1c
1.154(1.035-1.288)
0.010
1.06(0.902-1.247)
0.479
CreCl
0.988(0.98-0.997)
0.009
1.006(0.994-1.018)
0.353
HB
0.973(0.889-1.065)
0.553
—
—
WBC
0.961(0.904-1.021)
0.197
—
—
PLT
1.002(0.999-1.004)
0.124
—
—
CRP (mg/dl)
1(1-1.001)
0.117
—
—
MPV
1.288(1.112-1.492)
0.001
1.153(0.969-1.372)
0.109
WMR
0.548(0.339-0.885)
0.014
0.775(0.478-1.256)
0.01
LVEF
0.966(0.949-0.983)
<0.001
0.988(0.968-1.009)
0.266
GRACE
1.019(1.012-1.026)
<0.001
1.006(0.996-1.017)
0.228
RSS
1.087(1.064-1.11)
<0.001
1.074(1.047-1.102)
<0.001
CAD: coronary artery disease; CreCl: creatinine clearance; CRP: C-reactive protein; DM: diabetes mellitus; Hb: hemoglobin; HbA1C: hemoglobin A1C; HL: hyperlipidemia; HT: hypertension; LVEF: left ventricular ejection fraction; MPV: mean platelet volume; PLT: platelet; RSS: residual SYNTAX score; WBC: white blood cell; WMR: white blood cell count to mean platelet volume. Bold data are with statistical significance.
