Serum PCSK9 Correlates with PTX3 and Apolipoproteins B, A1, and C3 Concentrations in Patients with Type 2 Diabetes
Table 2
Characteristics of examined variables according to PCSK9 tertile concentrations.
Parameters
Tertiles PCSK9
1 ()
2 ()
3 ()
/Me
sd/IR
/Me
sd/IR
/Me
sd/IR
Age (yrs)
38
62.0
10.18
39
59.3
10.03
39
56.1
12.30
0.0619
Diabetes duration (yrs)
38
11.7
9.15
39
7.3
6.13
37
8.9
6.29
0.0308
HbA1c (%)
31
9.01
2.50
29
8.69
2.40
27
8.07
1.99
0.3044
Waist circumference (cm)
38
109.5
11.71
38
106.2
12.86
37
111.7
14.39
0.1802
BMI (kg/m2)
38
31.6
4.44
39
32.3
5.64
39
34.3
6.80
0.0968
SBP (mmHg)
38
129.0
15.95
39
130.8
18.91
38
131.4
19.63
0.8379
DBP (mmHg)
38
79.0
10.81
39
81.5
8.33
38
81.8
14.24
0.4896
TC (mmol/l)&
35
3.80
1.20
34
4.60
1.20
37
5.50
1.50
<0.001
TG (mmol/l)
35
1.50
0.84
34
1.62
1.10
37
2.06
1.30
0.0062
HDL-cholesterol (mmol/l)
35
1.11
0.292
34
1.14
0.374
37
1.16
0.236
0.8390
LDL-cholesterol (mmol/l)
35
2.03
0.725
32
2.45
0.908
31
3.42
1.349
<0.001
Glucose (mmol/l)
32
7.77
2.880
27
7.03
2.678
32
7.94
2.059
0.3595
Creatinine (mmol/l)
38
76.50
22.00
35
78.00
25.00
35
75.00
25.00
0.4548
Uric acid (μmol/l)
35
322
86.07
33
359
102.19
35
360
94.09
0.1642
PTX3 (ng/ml)
38
3.23
1.73
39
4.02
2.39
39
5.25
2.25
<0.001
apo B48 (ng/ml)
38
3417.5
2358.0
39
3695.0
2897.0
38
5241.5
3619.0
0.0167
apo B100 (mg/dl)
38
76.9
18.62
39
85.2
24.05
39
104.1
26.53
<0.001
apo A1 (mg/dl)
38
126.9
29.67
39
143.0
20.46
39
154.4
29.03
<0.001
apo C3 (μg/dl)
38
209.0
135.2
39
209.3
136.1
38
283.9
146.4
0.0029
sLDLr (ng/ml)
38
165.3
21.10
39
123.6
17.46
39
100.9
19.63
<0.001
FLI
34
82.69
23.30
33
85.33
31.54
33
92.54
19.92
0.0472
AST (U/L)
38
25.00
15.00
35
24.00
16.00
36
25.00
13.50
0.9424
ALT (U/L)
38
28.00
29.00
35
26.00
22.00
37
31.00
25.00
0.9889
GGTP (U/L)
36
29.00
20.50
35
28.00
27.00
35
30.00
42.00
0.5769
Due to the lack of normality of the distribution, the median (Me) and the interquartile range (IR) were given, and the Kruskal-Wallis test was used to assess the differences in distributions between PCSK9 tertiles; in the remaining cases, the mean () and standard deviation (sd) were given, and the ANOVA analysis of variance was used to evaluate the differences in the mean values between PCSK9 tertiles. &Due to the lack of homogeneity of the TC variance between PCSK9 tertiles, Me and IR were given for the description of TC, and the Kruskal-Wallis test was used to evaluate the differences between the distributions.
