Research Article

hsa_circWDR37_016 Regulates Hypoxia-Induced Proliferation of Pulmonary Arterial Smooth Muscle Cells

Figure 5

Bioinformatic analysis of circWDR37. (a) The ceRNA network contained circWDR37 (represented by yellow nodes), the top 5 sponging miRNAs (represented by green nodes), and the targeting mRNAs (represented by blue nodes). (b) Top 5 enriched GO terms of target genes of circWDR37. The ontology covers three domains: biological process, cellular component, and molecular function. The value produced by topGO indicated the significance of GO terms abundance in circWDR37 targeting genes. (c) Significantly enriched pathway terms. 10 pathways of the target genes of circWDR37 were identified using KEGG analysis according to the value. (d) Significantly enriched KEGG disease terms were identified by Kobas3.0 ( value ≤ 0.05). GO: Gene Oncology; KEGG: Kyoto Encyclopedia of Genes and Genomes.