Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice

Table 3

Parameters of survival, life span and tumorigenesis in PARP-1^−/− and PARP-1^+/+ mice.

Parameters	PARP-1^+/+	PARP-1^−/−
Number of mice	103	73
Mean life span (days, mean ± S.E.M.)	678±14.2	588±14.4^**
Median (days)	686	597
Mean life span of last 10% of survivors (days)	919±11.6	778±14.3^**
Maximum life span (days)	983	822
Aging rate, α (days^−1)	0.00771 (0.00760; 0.00782)	0.00932 (0.00926: 0.00956)^*
MRDT (days)	89.88 (88.6; 91.22)	74.36 (72.53; 74.89)^*
Number of tumor-bearing mice	79 (76.7%)	53 (72.6%)
Number of malignant tumor-bearing mice	48 (46.6%)	49 (67.1%)^***
Mean life span of tumor-bearing mice (days, mean ± S.E.M.)	706±17.6	612±19.2^**
Total number of tumors	120	82
Total number of malignant tumors	59 (49.2%)	59 (72.0%)^*

α in Gompertz model:𝑅=𝑅₀(exp)𝛼𝑡, where𝑅₀ = mortality rate in the time of 𝑡=0, 95% confidence limits are given in parentheses; MRDT, mortality rate doubling time.
The difference with the PARP-1^+/+ is significant:^*: 𝑃<.05; ^**: 𝑃<.002; ^***: 𝑃<.001.