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Current Gerontology and Geriatrics Research
Volume 2008 (2008), Article ID 858759, 7 pages
http://dx.doi.org/10.1155/2008/858759
Clinical Study

IDE Gene Polymorphism Influences on BPSD in Mild Dementia of Alzheimer's Type

1Department of Neuropsychiatry, Hyogo College of Medicine, Hyogo 663-8501, Japan
2Kaede Cocorono Hospital, Osaka 598-0002, Japan

Received 7 March 2008; Revised 14 July 2008; Accepted 3 October 2008

Academic Editor: George Kuchel

Copyright © 2008 Noriko Sato et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Insulin degrading enzyme (IDE) degrades amyloid 𝛽 (A 𝛽 ), which may inhibit the accumulation of A 𝛽 in a brain affected with dementia of Alzheimer's type (DAT). A decrease in the activity of IDE results in changes in glucose utilization in the brain, which could affect the cognitive and psychiatric symptoms of DAT. We investigated a possible association of IDE gene polymorphism and the behavioral and psychological symptoms of dementia (BPSD) in mild DAT. The genotyping for IDE and apolipoprotein E (ApoE) was determined in 207 patients with mild DAT and 215 controls. The occurrence of BPSD was demonstrated using the Behavioral Pathology in Alzheimer's Disease Rating Scale (BEHAVE-AD). IDE gene polymorphism is unlikely to play a substantial role in conferring susceptibility to DAT, but it may be involved in the development of affective disturbance through the course of mild DAT, regardless of the presence of an ApoE 𝜀 4 allele. The present data could be the result of a small sample size. Further investigations using larger samples are thus required to clarify the correlation between IDE gene polymorphism, susceptibility to DAT, and emergence of BPSD.