IDE Gene Polymorphism Influences on BPSD in Mild Dementia of Alzheimer's Type

Table 3

Genotype distributions and allele frequencies of IDE gene polymorphism in DAT patients with and without affective disturbance after stratification according to ApoE ε4 allele.

	IDE			IDE without ApoE ε4
	DAT with affective disturbance		DAT without affective disturbance	DAT with affective disturbance		DAT without affective disturbance
Gene polymorphism
T/T (%)	33 (48.5)		102 (73.4)	15 (41.7)		53 (79.1)
T/C (%)	30 (44.1)		33 (23.7)	17 (47.2)		11 (16.4)
C/C (%)	5 (7.4)		4 (2.9)	4 (11.1)		3 (4.5)
𝜒^2 value		12.66			14.66
𝑃-value		.0018^*			.0007^**
Allele frequency
T allele, %	70.6		85.3	65.3		87.3
C allele, %	29.4		14.7	34.7		12.7
𝜒^2 value		12.48			14.01
𝑃-value		.0004^+			.0002^++

^*P  =  .0126; ^**P  =  .0049, ⁺P  =  .0028; ⁺⁺P  =  .0014 after Bonferroni correction.