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Current Gerontology and Geriatrics Research
Volume 2011, Article ID 514059, 5 pages
http://dx.doi.org/10.1155/2011/514059
Clinical Study

Comparing the Neuropsychiatric Profile of Patients with Alzheimer Disease Who Present Spared versus Impaired Executive Functioning

1Cognitive Neuroscience Laboratory, Institute of Cognitive Neurology (INECO), Pacheco de Melo 1860, 1126 Buenos Aires, Argentina
2Laboratory of Cognitive Neuroscience, Universirty Diego Portales, 8370179 Santiago, Chile
3Institute of Neurosciences, Favaloro University, 1078 Buenos Aires, Argentina

Received 13 June 2011; Revised 1 September 2011; Accepted 1 September 2011

Academic Editor: Helen Lavretsky

Copyright Β© 2011 Ezequiel Gleichgerrcht et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Background. A “dysexecutive” group of patients with Alzheimer disease (AD) has been previously identified, and these patients have been found to present higher frequency of psychiatric symptoms and more pronounced functional impact. This study aimed at evaluating the frequency of neuropsychiatric symptoms in patients with early AD who present with impaired executive functioning. Methods. Thirty patients with early AD diagnosis were divided into a spared (SEF) and an impaired (IEF) executive functioning group according to their performance scores on neuropsychological tests. Their closest relatives or caregivers completed the Cambridge behavioral inventory (CBI), which assesses behavioral symptoms grouped into 13 categories. Results. A significant difference was exclusively found between SEF and IEF in terms of the frequency of stereotypies and repetitive motor behavior ( π‘ˆ = 6 0 . 5 , 𝑃 = . 0 2 4 ). Conclusions. The presence of stereotypies could be associated with a dysexecutive profile in AD patients. These results shed light on the role of frontal circuitry in the expression of motor symptoms in AD and prompt for further research that will contribute to the differential diagnosis both of different subtypes of AD and other types of dementia.