Verbal Episodic Memory and Endogenous Estradiol: An Association in Patients with Mild Cognitive Impairment and Alzheimer's Disease

Table 1

Demographic and clinical data of study subjects.

	Controls (𝑛=37)	MCI (𝑛=32)	AD (𝑛=117)	𝑃 value
Age (years)	60.7 ± 11.3^‡	65.5 ± 6.9	72.0 ± 8.6^‡	<0.001
MMSE*	29.2 ± 1.2^‡	28.1 ± 1.7	21.9 ± 8.6^‡	<0.001
Gender female/male	17/20	9/23^§	77/40^§	<0.001
E2 (pg/mL)	39.4 ± 31.3^‡,	29.8 ± 20.5	21.0 ± 14.5^‡	<0.001
0 APOE 𝜀4-isoallels	84.4%^‡	75.0%^§	38.7%^‡,§	<0.001
1	15.6%	18.8%	48.6%
2	0%	6.3%	12.6%
CVLT SD	14.0 ± 2.5^‡,¶	9.2 ± 3.8^§,¶	5.2 ± 2.8^‡,§	<0.001
CVLT LD	13.9 ± 2.6^‡,¶	9.2 ± 3.9^§,¶	4.5 ± 2.9^‡,§	<0.001
CVLT Rec	15.8 ± 0.5^‡,¶	14.2 ± 1.8^§,¶	12.4 ± 3.2^‡,§	<0.001

*Mini-Mental Status Exam.
Significant group differences (post hoc with Bonferroni correction): ^‡AD versus controls, ^§AD versus MCI, ^¶MCI versus controls.