Research Article
Dyslipidemia and Blood-Brain Barrier Integrity in Alzheimer's Disease
Table 1
Study population characteristics1.
| | Total () | BBB intact () | BBB impaired () |
| | Age, years | 70 (7.1) | 70 (7) | 73 (8) | | Female, no. (%) | 12 (33) | 11 (39) | 1 (13) | | ApoE-e4 allele carriers (%) | 27 (75) | 21 (75) | 6 (75) | | BMI (%) | 27 (4.6) | 26 (4) | 29 (6) | | BP, systole, mmHg | 142 (23.2) | 143 (21) | 137 (30) | | BP, diastole, mmHg | 78 (12.2) | 79 (13) | 76 (8) | | Mini mental state exam | 19 (5.0) | 20 (5) | 18 (5) | | Hachinski ischemia score | 0.6 (0.9) | 0.5 (0.8) | 1.0 (1.3) | | Statin use, no. (%) | 8 (22) | 5 (18) | 3 (38) | | Glucose, mg/dL | 99 (18) | 98 (18) | 101 (17) | | CSF albumin index | 7.2 (3.7) | 5.6 (1.7) | 12.9 (3.3)abc | | Atherogenic dyslipidemia, no. (%)2 | 15 (42) | 9 (32) | 6 (75)a | | Metabolic dyslipidemia, no. (%)2 | 17 (47) | 11 (39) | 6 (75)a | | Triglycerides, mg/dL | 215 (132) | 185 (86) | 323 (204)ab | | HDL cholesterol, mg/dL | 48 (20) | 52 (22) | 35 (5)a | | LDL cholesterol, mg/dL | 129 (33) | 132 (37) | 120 (10) | | Total cholesterol, mg/dL | 216 (36) | 218 (40) | 210 (27) |
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BBB: blood-brain barrier, ApoE-e4: apolipoprotein E epsilon 4, BMI: body mass index, BP: blood pressure, HDL: high-density lipoprotein, LDL: low-density lipoprotein.
1Mean and standard deviation provided unless stated otherwise; a, ab, abc.
2Atherogenic dyslipidemia: triglycerides ≥ 150 mg/dL, LDL > 100 mg/dL and HDL < 50 mg/dL [15].
3Metabolic dyslipidemia: triglycerides ≥ 150 mg/dL, HDL < 50 mg/dL [16].
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