Review Article

Pain Management in the Elderly: An FDA Safe Use Initiative Expert Panel’s View on Preventable Harm Associated with NSAID Therapy

Table 2

Barriers created during NSAID therapy.

Physician barriersPatient barriers

(1) Limited awareness of or failure to adhere to available NSAIDs Guidelines(1) Barriers to patient education regarding the proper use of medications
 (a) Too many guidelines (a) Power of TV ads on decision for what medications to take
 (b) Confusion about which guidelines are applicable to what segment of the elderly population (b) Limited awareness of the risks associated with medications
(2) Barriers to using available and up-to-date knowledge on NSAIDs(2) Failure to objectively, properly, and safely alleviate pain
 (a) Prevalence and intensity of pain sometimes clouds patients’ reasoning and leads to unsafe medication intake behavior
(3) Inability of primary health care providers to pursue education/training on how to adjust some of the medical practice aspects to the geriatric population(3) Economic factors
 (a) Cost of copayments sometimes deter from seeking professional and appropriate prescriptions
(4) Barriers to optimally manage patient’s pain which leads the patient to seek other sources of alleviating it(4) Misperception about the safety of OTC medications
 (a) Risk of overdosing, drug-drug interactions, and chronic use
 (b) Failure to recognize or legitimize the tell-tale signs of adverse events
(5) Limited physician-patient interchange regarding proper use and what to expect(5) Limited awareness of NSAID sources
 (a) OTC
 (b) Prescription
(6) Absence of systematic screening, monitoring, and educational procedures for prevention
 (a) Identify patients at high risk of renal impairment, GI bleed, cardiovascular side effects, and other AEs and manage them appropriately
 (b) Ask/document OTC use including NSAIDs and dietary supplements
 (c) Warn patients about specific NSAID serious adverse events
 (d) Make patient aware of medications that interact with NSAIDs
 (e) Educate patient about the risk of long-term use of NSAIDs
  (i) Ex. patients at high risk of CVD
 (f) Prescribe prophylactic measures
  (i) Ex. proton pump inhibitors
(7) Barriers to the use of new technological tools to improve prescribing
(8) Limited awareness of and evidence-based practice for nonpharmacologic approaches to pain reduction