Current Gerontology and Geriatrics Research / 2012 / Article / Tab 1

Review Article

The Impact of MicroRNAs on Brain Aging and Neurodegeneration

Table 1

List of miRNAs that are reported or have high probability to inhibit the expression of genes linked to neurodegenerative disease development.

DiseaseRisk genemiRNAReferences

Alzheimer’s diseaseA-betamiR-101[10]
Parkinson’s diseaseα-synucleinmiR-7, miR-153 [11]
Spinocerebellar ataxia type 1 (SCA1)Ataxin 1miR-144, miR-107, miR-130, miR-19[12, 13]
Amyotrophic lateral sclerosis (ALS)SOD1miR-206[14]

Spinocerebellar ataxia type 7 (SCA7)Ataxin 7miR-199*, miR-141*, miR-200a*[15, 16]
Huntington’s diseaseHuntingtinmiR-216*, miR-107*, miR-27ab*, miR-128*[15, 16]

*miRNAs that have high potential to inhibit ataxin 7 and Huntingtin gene expression as predicted by Target Scan (release 5.2).

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