The Impact of MicroRNAs on Brain Aging and Neurodegeneration

Table 1

List of miRNAs that are reported or have high probability to inhibit the expression of genes linked to neurodegenerative disease development.

Disease	Risk gene	miRNA	References
Alzheimer’s disease	A-beta	miR-101	[10]
Parkinson’s disease	α-synuclein	miR-7, miR-153	[11]
Spinocerebellar ataxia type 1 (SCA1)	Ataxin 1	miR-144, miR-107, miR-130, miR-19	[12, 13]
Amyotrophic lateral sclerosis (ALS)	SOD1	miR-206	[14]
Spinocerebellar ataxia type 7 (SCA7)	Ataxin 7	miR-199*, miR-141*, miR-200a*	[15, 16]
Huntington’s disease	Huntingtin	miR-216*, miR-107*, miR-27ab*, miR-128*	[15, 16]

*miRNAs that have high potential to inhibit ataxin 7 and Huntingtin gene expression as predicted by Target Scan (release 5.2).