Current Gerontology and Geriatrics Research / 2012 / Article / Tab 3

Research Article

Polymorphisms in HSD17B1: Early Onset and Increased Risk of Alzheimer’s Disease in Women with Down Syndrome

Table 3

Alzheimer's disease risk by HSD17B1 genotype in women with Down syndrome.

HSD17B1 genotype* ADHR (95% CI)**

rs2830
 CC4915 (30.6)0.7 (0.3.5)
 CT10131 (33.7)0.9 (0.5–1.8)
 TT5615 (26.8)1.0 (reference)
rs2676530
 AA147 (50.0)1.5 (0.7–3.3)
 AG7517 (22.7)0.7 (0.4–1.2)
 GG13547 (34.8)1.0 (reference)
rs676387
 TT229 (40.9)2.7 (1.25.8)
 GT7223 (31.9)1.4 (0.8–2.4)
 GG12940 (31.0)1.0 (reference)
rs605059
 CC5920 (33.9)3.0 (1.46.8)
 CT10734 (31.8)2.0 (0.98–4.2)
 TT5112 (23.5)1.0 (reference)
rs598126
 CC5815 (34.)2.2 (1.14.4)
 CT11937 (31.1)1.4 (0.7–2.6)
 TT5420 (27.8)1.0 (reference)

**Hazard ratio for AD, adjusted for age, ethnicity, level of intellectual disability, BMI, and the presence of an APOE ε4 allele.
*Numbers vary because not all participants were genotyped for all SNPs.