The Role of Insulin and Insulin-Like Growth Factor-1/FoxO-Mediated Transcription for the Pathogenesis of Obesity-Associated Dementia

Figure 3

FoxO phosphorylation sites regulated via different kinases. Abbreviations: PKB, protein kinase B/Akt; SGK, serum-and glucocorticoid-induced protein kinase; cGK, cGMP-dependent protein kinase type 1; MST1, mammalian sterile 20-like 1 kinase; CDK 2, cyclin-dependent kinase 2; CK1, casein kinase 1; DYRK, dual specificity tyrosine-phosphorylation-regulated kinase; JNK, c-Jun N-terminal kinase; IKK, IκB-kinase, NLS, nuclear localization signal; NES, nuclear export signal; FKH, forkhead domain; TA, transactivation domain.