Age-Related Neurodegeneration and Memory Loss in Down Syndrome

Figure 1

Mouse models for DS. Schematic of the gene segments involved in the so-called “Down syndrome critical region” (DSCR) in human chromosome 21, as well as in different mouse models of the condition. Note that the Ts65Dn mouse contains all genes included in the DSCR, as well as a set of 132 other genes including SOD and APP. Modified from Antonarakis et al. 2004 [21].