Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia

<table>Putative adaptation to OS in down syndrome. OS occurs early in DS pathogenesis and progression. Accumulation of oxidative damage leads to severe phenotypes while the induction of compensatory mechanisms in response to chronic OS could result in “adaptation” and could contribute to improve the life span of DS subjects.</table>

Current Gerontology and Geriatrics Research

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Figure 2: Oxidative Stress and Down Syndrome: A Route toward Alzheimer-Like Dementia 