Insulin degrading enzyme (IDE) degrades amyloid <svg style="vertical-align:-2.29482pt;width:8.8500004px;" id="M1" height="13.425" version="1.1" viewBox="0 0 8.8500004 13.425" width="8.8500004"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
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		</g>
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</svg> (A<svg style="vertical-align:-2.29482pt;width:8.8500004px;" id="M2" height="13.425" version="1.1" viewBox="0 0 8.8500004 13.425" width="8.8500004"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
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</svg>), which may inhibit the accumulation of A<svg style="vertical-align:-2.29482pt;width:8.8500004px;" id="M3" height="13.425" version="1.1" viewBox="0 0 8.8500004 13.425" width="8.8500004"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,13.425)">
		<g transform="translate(72,-61.26)">
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				<tspan style="font-size: 12.50px; " x="0" y="0">𝛽</tspan>
			</text>

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</svg> in a brain affected with dementia of Alzheimer&#x27;s type (DAT). A decrease in the activity of IDE results in changes in glucose utilization in the brain, which could affect the cognitive and psychiatric symptoms of DAT. We investigated a possible association of IDE gene polymorphism and the behavioral and psychological symptoms of dementia (BPSD) in mild DAT. The genotyping for IDE and apolipoprotein E (ApoE) was determined in 207 patients with mild DAT and 215 controls. The occurrence of BPSD was demonstrated using the Behavioral Pathology in Alzheimer&#x27;s Disease Rating Scale (BEHAVE-AD). IDE gene polymorphism is unlikely to play a substantial role in conferring susceptibility to DAT, but it may be involved in the development of affective disturbance through the course of mild DAT, regardless of the presence of an ApoE <svg style="vertical-align:-0.13794pt;width:7.6875px;" id="M4" height="7.1875" version="1.1" viewBox="0 0 7.6875 7.1875" width="7.6875"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,7.1875)">
		<g transform="translate(72,-66.25)">
			<text transform="matrix(1,0,0,-1,-71.95,66.44)">
				<tspan style="font-size: 12.50px; " x="0" y="0">𝜀</tspan>
			</text>

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</svg>4 allele. The present data could be the result of a small sample size. Further investigations using larger samples are thus required to clarify the correlation between IDE gene polymorphism, susceptibility to DAT, and emergence of BPSD.

Noriko Sato

Akinori Ueki

Hideo Ueno

Hidetaka Shinjo

Yoshio Morita

IDE Gene Polymorphism Influences on BPSD in Mild Dementia of Alzheimer&#39;s Type

We summarize here the studies examining the association between thyroid function and
 cognitive performance from an aging perspective. The available data suggest that there may be a continuum
  in which cognitive dysfunction can result from increased or decreased concentrations of thyroid 
  hormones. Clinical and subclinical hypothyroidism as well as hyperthyroidism in middle-aged and elderly 
  adults are both associated with decreased cognitive functioning, especially memory, visuospatial organization, 
  attention, and reaction time.  Mild variations of thyroid function, even within normal limits, can have significant 
  consequences for cognitive function in the elderly. Different cognitive deficits possibly related to thyroid failure 
  do not necessarily follow a consistent pattern, and L-thyroxine treatment may not always completely restore 
  normal functioning in patients with hypothyroidism.  There is little or no consensus in the literature regarding 
  how thyroid function is associated with cognitive performance in the elderly.

M. E. B&#233;gin

M. F. Langlois

D. Lorrain

S. C. Cunnane

Thyroid Function and Cognition during Aging

<i  >Background</i>. The aim of the present study was to investigate the relationships between personality and quality of life during the course of geriatric rehabilitation, against the background of Cloninger&#x27;s biosocial theory of personality. <i  >Methods</i>. All consecutive patients of a geriatric rehabilitation clinic during one year were evaluated at admission and discharge (<svg style="vertical-align:-0.17555pt;width:54.237499px;" id="M1" height="11.0375" version="1.1" viewBox="0 0 54.237499 11.0375" width="54.237499"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,11.0375)">
		<g transform="translate(72,-63.17)">
			<text transform="matrix(1,0,0,-1,-71.95,63.4)">
				<tspan style="font-size: 12.50px; " x="0" y="0">N</tspan>
				<tspan style="font-size: 12.50px; " x="12.490497" y="0">=</tspan>
				<tspan style="font-size: 12.50px; " x="24.530886" y="0">6</tspan>
				<tspan style="font-size: 12.50px; " x="30.782387" y="0">8</tspan>
				<tspan style="font-size: 12.50px; " x="37.033886" y="0">7</tspan>
			</text>

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	</g>
</svg>) by means of the &#x2018;&#x2018;Vienna List&#x2019;&#x2019; (a newly developed questionnaire for the assessment of quality of life in patients with severe dementia), and two variants of the Temperament and Character Inventory. 
<i  >Results</i>. Self-directedness showed the most general and highest impact on quality of life and successful rehabilitation. <i  >Conclusions</i>. It is probable in old and very old individuals who are on their highest level of maturity that the character represents the most important regulatory system in the encounter with challenges of daily life, which necessitates rehabilitation.

J&#246;rg Richter

Martina Schwarz

Barbara Bauer

Personality Characteristics Determine Health-Related 
                        Quality of Life as an Outcome Indicator of Geriatric Inpatient Rehabilitation

Cobalamin (vitamin B12) deficiency is particularly common in the elderly (&gt;65 years of age) but is often unrecognized because its clinical manifestations are subtle; however, they are also potentially serious, particularly from a neuropsychiatric and hematological perspective. In the elderly, the main causes of cobalamin deficiency are pernicious anemia and food-cobalamin malabsorption. Food-cobalamin malabsorption syndrome is a disorder characterized by the inability to release cobalamin from food or its binding proteins. This syndrome is usually caused by atrophic gastritis, related or unrelated to <i>Helicobacter pylori</i> infection, and long-term ingestion of antacids and biguanides. Management of cobalamin deficiency with cobalamin injections is currently well documented but new routes of cobalamin administration (oral and nasal) are being studied, especially oral cobalamin therapy for food-cobalamin malabsorption.

Emmanuel Andrès

Thomas Vogel

Laure Federici

Jacques Zimmer

Ecaterina Ciobanu

Georges Kaltenbach

Cobalamin Deficiency in Elderly Patients: A Personal View

Genetic and biochemical studies have shown that PARP-1 and poly(ADP-ribosyl)ation play an important role in DNA repair, genomic stability, cell death, inflammation, telomere maintenance, and suppressing tumorigenesis, suggesting that the homeostasis of poly(ADP-ribosyl)ation and PARP-1 may also play an important role in aging. Here we show that PARP-<svg style="vertical-align:-0.0pt;width:26.5875px;" id="M1" height="13.9875" version="1.1" viewBox="0 0 26.5875 13.9875" width="26.5875"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,13.9875)">
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</svg> mice exhibit a reduction of life span and a significant increase of population aging rate. Analysis of noninvasive parameters, including body weight gain, body temperature, estrous function, behavior, and a number of biochemical indices suggests the acceleration of biological aging in PARP-<svg style="vertical-align:-0.0pt;width:26.5875px;" id="M2" height="13.9875" version="1.1" viewBox="0 0 26.5875 13.9875" width="26.5875"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,13.9875)">
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			</text>

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</svg> mice. The incidence of spontaneous tumors in both PARP-<svg style="vertical-align:-0.0pt;width:26.5875px;" id="M3" height="13.9875" version="1.1" viewBox="0 0 26.5875 13.9875" width="26.5875"  xmlns="http://www.w3.org/2000/svg">
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</svg> and PARP-<svg style="vertical-align:-0.0pt;width:26.5875px;" id="M4" height="13.9875" version="1.1" viewBox="0 0 26.5875 13.9875" width="26.5875"  xmlns="http://www.w3.org/2000/svg">
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</svg> groups is similar; however, malignant tumors including uterine tumors, lung adenocarcinomas and hepatocellular carcinomas, develop at a significantly higher frequency in PARP-<svg style="vertical-align:-0.0pt;width:26.5875px;" id="M5" height="13.9875" version="1.1" viewBox="0 0 26.5875 13.9875" width="26.5875"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,13.9875)">
		<g transform="translate(72,-60.81)">
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			</text>

			<text transform="matrix(1,0,0,-1,-65.7,66.03)">
				<tspan style="font-size: 8.75px; " x="0" y="0">−</tspan>
				<tspan style="font-size: 8.75px; " x="5.99512" y="0">/</tspan>
				<tspan style="font-size: 8.75px; " x="8.4281759" y="0">−</tspan>
			</text>

		</g>
	</g>
</svg> mice than PARP-<svg style="vertical-align:-0.0pt;width:26.5875px;" id="M6" height="13.9875" version="1.1" viewBox="0 0 26.5875 13.9875" width="26.5875"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,13.9875)">
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				<tspan style="font-size: 8.75px; " x="0" y="0">+</tspan>
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			</text>

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</svg> mice (72&#x25; and 49&#x25;, resp.; <svg style="vertical-align:-0.30096pt;width:24.450001px;" id="M7" height="10.7" version="1.1" viewBox="0 0 24.450001 10.7" width="24.450001"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,10.7)">
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				<tspan style="font-size: 12.50px; " x="0" y="0">𝑃</tspan>
				<tspan style="font-size: 12.50px; " x="10.890113" y="0">&lt;</tspan>
			</text>

		</g>
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</svg> .05). In addition, spontaneous tumors appear earlier in PARP-<svg style="vertical-align:-0.0pt;width:26.5875px;" id="M8" height="13.9875" version="1.1" viewBox="0 0 26.5875 13.9875" width="26.5875"  xmlns="http://www.w3.org/2000/svg">
	<g transform="matrix(1.25,0,0,-1.25,0,13.9875)">
		<g transform="translate(72,-60.81)">
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				<tspan style="font-size: 12.50px; " x="0" y="0">1</tspan>
			</text>

			<text transform="matrix(1,0,0,-1,-65.7,66.03)">
				<tspan style="font-size: 8.75px; " x="0" y="0">−</tspan>
				<tspan style="font-size: 8.75px; " x="5.99512" y="0">/</tspan>
				<tspan style="font-size: 8.75px; " x="8.4281759" y="0">−</tspan>
			</text>

		</g>
	</g>
</svg> mice compared to the wild type group. Histopathological studies revealed a wide spectrum of tumors in uterus, ovaries, liver, lungs, mammary gland, soft tissues, and lymphoid organs in both groups of the mice. These results demonstrate that inactivation of DNA repair gene PARP-1 in mice leads to acceleration of aging, shortened life span, and increased spontaneous carcinogenesis.

Tatiana S. Piskunova

Maria N. Yurova

Anton I. Ovsyannikov

Anna V. Semenchenko

Mark A. Zabezhinski

Irina G. Popovich

Zhao-Qi Wang

Vladimir N. Anisimov

Deficiency in Poly(ADP-ribose) Polymerase-1 (PARP-1) Accelerates Aging and Spontaneous Carcinogenesis in Mice

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<p><em>Current Gerontology and Geriatrics Research</em> publishes research based on molecular, cellular, organismal aspects of gerontological research and in diagnosis, treatment, evaluation and educational aspects of geriatrics research.</p>


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Current Gerontology and Geriatrics Research publishes research based on molecular, cellular, organismal aspects of gerontological research and in diagnosis, treatment, evaluation and educational aspects of geriatrics research.

Current Gerontology and Geriatrics Research