Mechanisms and Implications of Age-Related Changes in the Liver
1Centre for Education and Research on Ageing and ANZAC Research Institute, University of Sydney, Concord, NSW 2139, Australia
2Departments of Clinical Pharmacology and Aged Care, Royal North Shore Hospital and University of Sydney, St Leonards, NSW 2065, Australia
3Department of Cell Biology and Histology, University of Tromsø, 9037 Tromsø, Norway
Mechanisms and Implications of Age-Related Changes in the Liver
Description
Despite the fact that aging is the major independent risk factor for most diseases, there is almost no understanding of how old age predisposes to disease. The age-related decrease in liver function is substantial and very relevant for systemic exposure to substrates implicated in disease pathogenesis and aging.
We invite investigators to contribute original research articles as well as review articles that will stimulate the continuing efforts to understand the underlying mechanisms and implications of age-related changes in the liver, the development of strategies to attenuate and overcome these conditions, and the evaluation of outcomes. Potential topics include, but are not limited to:
- Changes to the hepatic sinusoid in aging
- Aging, cancer, and the liver
- Changes in drug toxicity in aging
- Complexity of hepatic drug metabolism in old age
- The liver and aging: implications for immune diseases
- Caloric restriction and the aging liver
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