Cisplatin Tumor Biodistribution and Efficacy after Intratumoral Injection of a Biodegradable Extended Release Implant

Figure 1

In vitro cumulative release of Pt from P(SA : RA)2 : 8 (triangles, dashed line) and P(SA : RA)3 : 7 (stars, solid line) loaded with 5% w/w cisplatin. Each point represents the mean value ± STD (𝑛=3). Release was conducted in 0.1 M phosphate buffer, pH 7.4, at 37°C. Pt concentrations were determined by ICP-MS.