Development of an Oral Form of Azacytidine: 𝟐^′𝟑^′𝟓^′Triacetyl-5-Azacytidine

Figure 1

Chemical synthesis of 2′,3′,5′-triacetyl-5-Azacytidine. Results of analytical 1H NMR (CDCl3, 500 MHz): d 8.18(s, 1H), 7.69(s, 1H), 6.33(s, 1H), 5.82(d, 1H, J = 3.0 Hz), 5.54(t, 1H, J = 4.0 Hz), 5.41(t, 1H, J = 6.0 Hz), 4.30–4.41(m, 3H), 2.11(s, 3H), 2.10(s, 3H), and 2.08(s, 3H) ppm. 13C NMR (CDCl3, 125 MHz): d 170.3, 169.6, 169.5, 166.0, 156.0, 153.1, 89.7, 79.9, 73.7, 69.9, 62.8, 20.7, 20.4, and 20.3 ppm.