Table of Contents
Chemotherapy Research and Practice
Volume 2012 (2012), Article ID 198197, 15 pages
http://dx.doi.org/10.1155/2012/198197
Review Article

Antiepidermal Growth Factor Receptor Monoclonal Antibodies: Applications in Colorectal Cancer

1Beth Israel Medical Center, Phillips Ambulatory Care Center, Continuum Cancer Centers of New York, 10 Union Square East, Suite 4C, New York, NY, USA
2Section of Hematology/Oncology, Department of Medicine, Albert Einstein College of Medicine, Bronx, NY, USA

Received 16 April 2012; Accepted 12 June 2012

Academic Editor: Basil El-Rayes

Copyright © 2012 Efat Azizi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. N. Howlader, A. M. Noone, M. Krapcho et al., “SEER Cancer Statistics Review, 1975–2008,” National Cancer Institute, Bethesda, Md, USA, 2011, http://seer.cancer.gov/csr/1975_2009_pops09/index.html.
  2. American Cancer Society, “Colorectal Facts & Figures 2011–2013”.
  3. C. R. Garrett and C. Eng, “Cetuximab in the treatment of patients with colorectal cancer,” Expert Opinion on Biological Therapy, vol. 11, no. 7, pp. 937–949, 2011. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Ng and A. X. Zhu, “Targeting the epidermal growth factor receptor in metastatic colorectal cancer,” Critical Reviews in Oncology/Hematology, vol. 65, no. 1, pp. 8–20, 2008. View at Publisher · View at Google Scholar · View at Scopus
  5. L. Vecchionea, B. Jacobsa, N. Normannoc, F. Ciardiellod, and S. Tejpar, “EGFR-targeted therapy,” Experimental Cell Research, vol. 317, no. 19, pp. 2765–2771, 2011. View at Publisher · View at Google Scholar
  6. J. Mendelson, “Targeting the epidermal growth factor receptor for cancer therapy,” Journal of Clinical Oncology, vol. 20, no. 18, supplement, pp. 1S–13S, 2002. View at Google Scholar
  7. L. B. Saltz, N. J. Meropol, P. J. Loehrer, M. N. Needle, J. Kopit, and R. J. Mayer, “Phase II trial of cetuximab in patients with refractory colorectal cancer that expresses the epidermal growth factor receptor,” Journal of Clinical Oncology, vol. 25, pp. 5225–5232, 2004. View at Google Scholar
  8. D. J. Jonker, C. J. O'Callaghan, C. S. Karapetis et al., “Cetuximab for the treatment of colorectal cancer,” The New England Journal of Medicine, vol. 357, pp. 2040–2048, 2007. View at Publisher · View at Google Scholar
  9. M. Peeters, E. Van Cutsem, S. Siena et al., “A phase III, multicenter, randomized controlled trial of panitumumab plus best supportive care (BSC) vs BSC alone in patients with metastatic colorectal cancer,” in Proceedings of the 97th Annual Meeting of the American Association for Cancer Research, vol. 47, April 2006, abstract no. CP-1.
  10. D. Cunningham, Y. Humblet, S. Siena et al., “Cetuximab monotherapy and cetuximab plus irinotecan in irinotecan- refractory metastatic colorectal cancer,” The New England Journal of Medicine, vol. 351, no. 4, pp. 337–345, 2004. View at Publisher · View at Google Scholar · View at Scopus
  11. A. F. Sobrero, J. Maurel, L. Fehrenbacher et al., “EPIC: phase III trial of cetuximab plus irinotecan after fluoropyrimidine and oxaliplatin failure in patients with metastatic colorectal cancer,” Journal of Clinical Oncology, vol. 26, no. 14, pp. 2311–2319, 2008. View at Publisher · View at Google Scholar · View at Scopus
  12. C. Lockhart and J. D. Berlin, “The epidermal growth factor receptor as a target for colorectal cancer therapy,” Seminars in Oncology, vol. 32, no. 1, pp. 52–60, 2005. View at Publisher · View at Google Scholar · View at Scopus
  13. B. Markman, F. Javier Ramos, J. Capdevila, and J. Tabernero, “EGFR and KRAS in colorectal cancer,” Advances in Clinical Chemistry, vol. 51, pp. 71–119, 2010. View at Publisher · View at Google Scholar · View at Scopus
  14. R. G. Amado, M. Wolf, M. Peeters et al., “Wild-type KRAS is required for panitumumab efficacy in patients with metastatic colorectal cancer,” Journal of Clinical Oncology, vol. 26, no. 10, pp. 1626–1634, 2008. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Bohanes, M. J. LaBonte, T. Winder, and H. J. Lenz, “Predictive molecular classifiers in colorectal cancer,” Seminars in Oncology, vol. 38, no. 4, pp. 576–587, 2011. View at Publisher · View at Google Scholar · View at Scopus
  16. A. Lièvre, J.-B. Bachet, D. Le Corre et al., “KRAS mutation status is predictive of response to cetuximab therapy in colorectal cancer,” Cancer Research, vol. 66, no. 8, pp. 3992–3995, 2006. View at Publisher · View at Google Scholar · View at Scopus
  17. F. A. Monzon, S. Ogino, M. E. H. Hammond, K. C. Halling, K. J. Bloom, and M. N. Nikiforova, “The role of KRAS mutation testing in the management of patients with metastatic colorectal cancer,” Archives of Pathology and Laboratory Medicine, vol. 133, no. 10, pp. 1600–1606, 2009. View at Google Scholar · View at Scopus
  18. M. T. Seymour, S. R. Brown, S. Richman et al., “Addition of panitumumab to irinotecan: results of PICCOLO, a randomized controlled trial in advanced colorectal cancer,” Journal of Clinical Oncology, vol. 29, supplement, abstract no. 3523, 2011. View at Google Scholar
  19. A. F. Sobrero, M. Peeters, T. J. Price et al., “Final results from study 181: randomized phase III study of FOLFIRI with or without panitumumab for the treatment of second-line metastatic colonorectal cancer,” Journal of Clinical Oncology, vol. 30, supplement 4, abstract no. 387, 2012. View at Google Scholar
  20. E. Van Cutsem, C. H. Köhne, E. Hitre et al., “Cetuximab and chemotherapy as initial treatment for metastatic colorectal cancer,” The New England Journal of Medicine, vol. 360, no. 14, pp. 1408–1417, 2009. View at Publisher · View at Google Scholar · View at Scopus
  21. C. Bokemeyer, I. Bondarenko, A. Makhson et al., “Fluorouracil, leucovorin, and oxaliplatin with and without cetuximab in the first-line treatment of metastatic colorectal cancer,” Journal of Clinical Oncology, vol. 27, no. 5, pp. 663–671, 2009. View at Publisher · View at Google Scholar · View at Scopus
  22. J. Y. Douillard, S. Siena, J. Cassidy et al., “Randomized, Phase III trial of panitumumab with infusional fluorouracil, leucovorin, and oxaliplatin (FOLFOX4) Versus FOLFOX4 alone as first-line treatment in patients with previously untreated metastatic colorectal cancer: the PRIME study,” Journal of Clinical Oncology, vol. 28, no. 31, pp. 4697–4705, 2010. View at Publisher · View at Google Scholar · View at Scopus
  23. B. J. Giantonio, P. J. Catalano, N. J. Meropol et al., “Bevacizumab in combination with oxaliplatin, fluorouracil, and leucovorin (FOLFOX4) for previously treated metastatic colorectal cancer: results from the Eastern Cooperative Oncology Group Study E3200,” Journal of Clinical Oncology, vol. 25, no. 12, pp. 1539–1544, 2007. View at Publisher · View at Google Scholar · View at Scopus
  24. H. Hurwitz, L. Fehrenbacher, W. Novotny et al., “Bevacizumab plus irinotecan, fluorouracil, and leucovorin for metastatic colorectal cancer,” The New England Journal of Medicine, vol. 350, no. 23, pp. 2335–2342, 2004. View at Publisher · View at Google Scholar · View at Scopus
  25. L. B. Saltz, H. J. Lenz, H. L. Kindler et al., “Randomized phase II trial of cetuximab, bevacizumab, and irinotecan compared with cetuximab and bevacizumab alone in irinotecan-refractory colorectal cancer: the BOND-2 study,” Journal of Clinical Oncology, vol. 25, no. 29, pp. 4557–4561, 2007. View at Publisher · View at Google Scholar · View at Scopus
  26. N. H. Segal, D. Reidy-Lagunes, M. Capanu et al., “Phase II study of bevacizumab in combination with cetuximab plus irinotecan in irinotecan-refractory colorectal cancer patients who have progressed on a bevacizumab-containing regimen: the BOND 2.5 Study,” Journal of Clinical Oncology, vol. 27, no. 15s, supplement, abstract no. 4087, 2009. View at Google Scholar
  27. J. Tol, M. Koopman, A. Cats et al., “Chemotherapy, bevacizumab, and cetuximab in metastatic colorectal cancer,” The New England Journal of Medicine, vol. 360, pp. 563–572, 2009. View at Publisher · View at Google Scholar
  28. J. R. Hecht, E. Mitchell, T. Chidiac et al., “A randomized phase IIIB trial of chemotherapy, bevacizumab, and panitumumab compared with chemotherapy and bevacizumab alone for metastatic colorectal cancer,” Journal of Clinical Oncology, vol. 27, no. 5, pp. 672–680, 2009. View at Publisher · View at Google Scholar · View at Scopus
  29. L. Saltz, S. Badarinath, S. Dakhil et al., “Phase III trial of cetuximab, bevacizumab, and 5-fluorouracil/leucovorin vs. FOLFOX-bevacizumab in colorectal cancer,” Clinical Colorectal Cancer, vol. 11, no. 2, pp. 101–111, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. C. J. Punt, J. Tol, C. J. Rodenburg et al., “Randomized phase III study of capecitabine, oxaliplatin, and bevacizumab with or without cetuximab in advanced colorectal cancer (ACC), the CAIRO2 study of the Dutch Colorectal Cancer Group (DCCG),” Journal of Clinical Oncology, vol. 26, supplement, abstract no. LBA4011, 2008. View at Google Scholar
  31. L. Siu et al., “Phase III randomized trial of cetuximab plus either brivanib alanin or placebo in patients with metastatic chemotherapy refractory K-RAS wild-type colorectal carcinoma: the NCIC Clinical Trials Group and AGITG CO. 20 Trial,” Journal of Clinical Oncology, vol. 30, supplement 4, abstract no. 386, 2012. View at Google Scholar
  32. D. J. Watkins, J. Tabernero, H. Schmoll et al., “A randomized phase II/III study of the anti-IGF-1R antibody MK-0646 (dalotuzumab) in combination with cetuximab and irinotecan in the treatment of chemorefractory metastatic colorectal cancer with wild-type KRAS status2011,” Journal of Clinical Oncology, vol. 29, supplement, abstract no. 3501.
  33. M. Goldberg, D. J. Sargent, S. N. Thibodeau et al., “Adjuvant mFOLFOX6 plus or minus cetuximab in patients with KRAS mutant resected stage III colon cancer: NCCTG Intergroup Phase III trial N0147,” Journal of Clinical Oncology, vol. 28, no. 15s, supplement, abstract no. 3508, 2010. View at Google Scholar
  34. J. Huang, D. J. Sargent, M. R. Mahoney et al., “Adjuvant FOLFIRI with or without cetuximab in patients with resected stage III colon cancer: NCCTG Intergroup Phase III trial N0147,” Journal of Clinical Oncology, vol. 29, supplement 4, abstract no. 363, 2011. View at Google Scholar
  35. J. Taieb, P. L. Puig, and L. Bedenne, “Cetuximab plus FOLFOX-4 for fully resected stage III colon carcinoma: scientific background and the ongoing PETACC-8 trial,” Expert Review of Anticancer Therapy, vol. 8, no. 2, pp. 183–189, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. G. Folprecht, T. Gruenberger, W. O. Bechstein et al., “Tumour response and secondary resectability of colorectal liver metastases following neoadjuvant chemotherapy with cetuximab: the CELIM randomised phase 2 trial,” The Lancet Oncology, vol. 11, no. 1, pp. 38–47, 2010. View at Publisher · View at Google Scholar · View at Scopus
  37. J. P. Machiels, C. Sempoux, P. Scalliet et al., “Phase I/II study of preoperative cetuximab, capecitabine, and external beam radiotherapy in patients with rectal cancer,” Annals of Oncology, vol. 18, no. 4, pp. 738–744, 2007. View at Publisher · View at Google Scholar · View at Scopus
  38. K. M. Sullivan and P. S. Kozuch, “Impact of KRAS mutations on management of colorectal carcinoma: pathology Research International,” vol. 2011, Article ID 219309, 11 pages, 2011. View at Publisher · View at Google Scholar
  39. A. J. Weickhardt, T. J. Price, N. Pavlakis et al., “DUX study: a phase II study of evaluating dual targeting of the EGFR using the combination of cetuximab and erlotinib in patients with chemotherapy refractory metastatic colorectal cancer,” Journal of Clinical Oncology, vol. 28, no. 15s, supplement, abstract no. 3533, 2010. View at Google Scholar
  40. A. Dasari and W. A. Messersmith, “New strategies in colorectal cancer: biomarkers of response to epidermal growth factor receptor monoclonal antibodies and potential therapeutic targets in phosphoinositide 3-kinase and mitogen-activated protein kinase pathways,” Clinical Cancer Research, vol. 16, no. 15, pp. 3811–3818, 2010. View at Publisher · View at Google Scholar · View at Scopus
  41. P. Laurent-Puig, A. Cayre, G. Manceau et al., “Analysis of PTEN, BRAF, and EGFR status in determining benefit from cetuximab therapy in wild-type KRAS metastatic colon cancer,” Journal of Clinical Oncology, vol. 27, no. 35, pp. 5924–5930, 2009. View at Publisher · View at Google Scholar · View at Scopus
  42. A. Ruzzo, C. Cremolini, F. Loupakis et al., “Association of BRAF mutations and EGFR Intron-1 L/L genotype with resistance to cetuximab plus irinotecan treatment in KRAS wild-type metastatic colon cancer patients,” Journal of Clinical Oncology, vol. 27, no. 15s, supplement, abstract no. 4058, 2009. View at Google Scholar
  43. C. Bokemeyer, E. V. Cutsem, P. Rougier et al., “Addition of cetuximab to chemotherapy as first-line treatment for KRAS wild-type metastatic colorectal cancer: pooled analysis of the CRYSTAL and OPUS randomized clinical trials,” European Journal of Cancer, vol. 48, no. 10, pp. 1466–1475, 2012. View at Google Scholar
  44. C. J. O'Callaghan, D. Tu, C. S. Karapetis et al., “The relationship between the development of rash and clinical and quality of life outcomes by KRAS mutation status in patients with colorectal cancer treated with cetuximab in NCIC CTG CO.17,” Journal of Clinical Oncology, vol. 29, supplement 4, abstract no. 481, 2011. View at Google Scholar
  45. M. Ychou, O. Bouche, S. Thézenas et al., “Final results of a multicenter phase II trial assessing sorafenib in combination with irinotecan as second-or later-line treatment in metastatic colorectal cancer patients with KRAS-mutated tumors: NEXIRI2011,” Journal of Clinical Oncology, vol. 29, supplement, abstract no. e14002, 2011. View at Google Scholar
  46. S. Kopetz, J. Desai, E. Chan et al., “PLX4032 in metastatic colorectal cancer patients with mutant BRAF tumors,” Journal of Clinical Oncology, vol. 28, no. 15s, supplement, abstract no. 3534, 2010. View at Google Scholar
  47. R. C. Wadlow, A. F. Hezel, T. A. Abrams et al., “Panitumumab in patients with KRAS wild-type colorectal cancer after progression on cetuximab,” Oncologist, vol. 17, no. 1, 14 pages, 2012. View at Publisher · View at Google Scholar · View at Scopus
  48. B. M. Wolpin, J. A. Meyerhardt, H. J. Mamon, and R. J. Mayer, “Adjuvant treatment of colorectal cancer,” CA Cancer Journal for Clinicians, vol. 57, no. 3, pp. 168–185, 2007. View at Publisher · View at Google Scholar · View at Scopus
  49. B. Melosky, R. Burkes, D. Rayson, T. Alcindor, N. Shear, and M. Lacouture, “Management of skin rash during EGFR-targeted monoclonal antibody treatment for gastrointestinal malignancies: Canadian recommendations,” Current Oncology, vol. 16, no. 1, pp. 16–26, 2009. View at Google Scholar · View at Scopus
  50. E. Van Cutsem, Y. Humblet, H. Gelderblom et al., “Cetuximab dose-escalation study in patients with metastatic colorectal cancer with no or slight skin reactions on cetuximab standard dose treatment (EVEREST): pharmacokinetic and efficacy data of randomized study,” in Proceedings of the Gastrointestinal Cancer Symposium, 2007, abstract no. 237.
  51. E. P. Mitchell, M. Lacouture, H. Shearer et al., “Final STEPP results of prophylactic versus reactive skin toxicity treatment for panitumumab-related skin toxicity in patients with metastatic colorectal cancer,” Journal of Clinical Oncology, vol. 27, no. 15s, supplement, abstract no. CRA4027, 2009. View at Google Scholar
  52. M. Fakih, “Management of anti-EGFR-targeting monoclonal antibody-induced hypomagnesemia,” Oncology, vol. 22, no. 1, pp. 74–76, 2008. View at Google Scholar · View at Scopus
  53. D. Schrag, K. Y. Chung, C. Flombaum, and L. Saltz, “Cetuximab therapy and symptomatic hypomagnesemia,” Journal of the National Cancer Institute, vol. 97, no. 16, pp. 1221–1224, 2005. View at Publisher · View at Google Scholar · View at Scopus
  54. M. Fakih and M. Vincent, “Adverse events associated with anti-EGFR therapies for the treatment of metastatic colorectal cancer,” Current Oncology, vol. 17, supplement 1, pp. S18–S30, 2010. View at Google Scholar