Anti-Inflammatory Cytokines: Important Immunoregulatory Factors Contributing to Chemotherapy-Induced Gastrointestinal Mucositis

Figure 2

Diagram illustrating the JAK-STAT signal transduction pathway activated by anti-inflammatory cytokine, Interleukin-10. IL-10 binds its high-affinity extracellular IL-10 receptors in a homodimeric form which leads to intracellular receptor-associated Janus tyrosine kinases, JAK-1 and TYK-2. These activated kinases serve a temporary docking-sites for the cytosolic STAT-3 via their phosphorylated SH-2 domain. Activated STAT-3 translocates to the nucleus and binds to STAT Binding Element (SBE) to promote a wide range of IL-10 responsive genes.