Table of Contents
Chemotherapy Research and Practice
Volume 2013, Article ID 386809, 7 pages
Review Article

Neoadjuvant Chemotherapy prior to Radical Prostatectomy for Patients with High-Risk Prostate Cancer: A Systematic Review

Department of Urology, Patras University Hospital, 26500 Patras, Greece

Received 23 December 2012; Accepted 22 January 2013

Academic Editor: Vassilios A. Georgoulias

Copyright © 2013 Stavros Sfoungaristos et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


High-risk prostate cancer represents a pretentious clinical problem since a significant number of its patients will relapse and progress after radical prostatectomy. Neoadjuvant chemotherapy may be valuable since its efficacy in hormone-resistant prostate cancer has been established. In this paper, we report studies of neoadjuvant chemotherapies that have been used in high-risk patients prior to radical prostatectomy. Even though the results regarding the prognostic surrogates are not significant, the effects on clinical and pathological outcomes are promising, while toxicity in most of the studies is in the expected field.