Review Article
Imatinib: A Breakthrough of Targeted Therapy in Cancer
Table 1
Response criteria in CML.
| | Response | Criteria |
| | Complete hematologic response (CHR) | Platelets <450 × /L
White cells <10 × /L
No circulating immature myeloid cells <5% basophils on differential
No palpable splenomegaly |
| | Minimal cytogenetic response (Minimal CR) | 66–95% Ph+ cells* |
| | Minor cytogenetic response (Minor CR) | 36–65% Ph+ cells* |
| | Partial cytogenetic response (PCR) | 1–35% Ph+ cells* |
| | Complete cytogenetic response (CCR) | No Ph+ cells* |
| | Major molecular response (MMR) | BCR-ABL ≤0.10% (international scale) |
| | Complete molecular response (CMR) | BCR-ABL transcripts nonquantifiable and nondetectable |
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At least 20 metaphases analysed on conventional cytogenetics of bone marrow aspirate.
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