Alternative Methods to Treat Nausea and Vomiting from Cancer Chemotherapy

Table 1

The effect of medicinal therapy on the intensity of nausea and vomiting in cancer patients under chemotherapy.

Study	Year	Sample size	Design/population	Method	Outcome
Ekangaki and Chung [5]	2005	450	Cancer patients under chemotherapy in two various age-gender groups	Case-control	The application of histamines, phenothiazines, butyrophenones, and anticholinergics to cope with CINV in chemotherapy brings about side effects
Sirin and Flynn [6]	2013	52	Cancer patients under chemotherapy in two various age-gender groups	Case-control	CINV was reduced by about %13.8 in the group receiving dimenhydrinate as compared to placebo
Pierce and Lin [7]	2013	85	Over 30-year-old men with prostate cancer under chemotherapy	Case-control	Prescribing dimenhydrinate for men with prostate cancer under chemotherapy has reduced their CINV as compared to control group
Sheanakul et al. [8]	2011	30	Below 60-year-old cancer patients under chemotherapy in two gender groups	Case-control	The continuous injection of midazolam has reduced pain and CINV in test group as compared to control group
Apfel et al. [9]	2012	23	15–50 years of age cancer patients under chemotherapy in two gender groups	Case-control	Cinnarizine controls and reduces CINV in cancer patients under chemotherapy as compared to placebo group through hindering histaminic H1 receptor
Rosenthal et al. [10]	2010	64	Over 12-year-old cancer patients under chemotherapy in two various gender groups	Clinical trial	Metoclopramide reduces CINV in cancer patients under chemotherapy through enhancing the activity threshold of CTZ chemical receptors
Denehy et al. [11]	2011	85	Cancer patients under chemotherapy in two various age-gender groups	Case-control	CINV is less in cancer patients under chemotherapy receiving metoclopramide as compared to the group receiving placebo