Figure 1: Amino acid sequence alignments for human and other vertebrate CEL subunits. See Table 1 for sources of CEL sequences; * shows identical residues for CEL subunits;: similar alternate residues;. dissimilar alternate residues; N-Signal peptide residues are in red; N-glycosylation residues at 207NIT (human CEL) are in green; active site (AS) triad residues Ser, Asp, and His are in pink; O-glycosylation sites are in blue; disulfide bond Cys residues for human CEL (•); essential arginines which contribute to bile-salt binding are in red; helix (human CEL or predicted helix); sheet (human CEL) or predicted sheet; bold font shows known or predicted exon junctions; exon numbers refer to human CEL gene; CEL “loop” covering the active site (human CEL residues 136–143) are in green; Hu-human CEL; Co-cow CEL; Mo-mouse CEL; Op-opossum CEL; Ch-chicken CEL; Z1-zebrafish CEL1; Z2-zebrafish CEL2.