MicroRNA Regulation of Cholesterol Metabolism

Table 1

MicroRNAs involved in cholesterol metabolism.

miRNA	Target tissue/cell type	Target genes	Biological function	References
miR-122	Primary mouse hepatocytes	ALDOA; CS	Glucose homeostasis; Krebs cycle	[22, 23]
miR-33a and; miR-33b	Liver and; macrophage	ABCA1; ABCG1; NPC1; CROT; HADHB; CPT1; SIRT6; PRKAA1; IRS2	Cellular cholesterol efflux; Fatty acid oxidation; Insulin signaling	[12, 24, 25]
miR-758	Human and mouse macrophages and hepatic cell line	ABCA1	Cellular cholesterol efflux	[13]
	Human neuroglioma cell line	SLC38a1; NTM; EPHA7	Aminoacid synthesis, neurite outgrowing, and neuronal migration
miR-106b	Mouse neuroblastoma cell line and human hepatocyte	ABCA1	Cellular cholesterol efflux and Aβ production	[14]