Assessment of Metformin as an Additional Treatment to Therapeutic Lifestyle Changes in Pediatric Patients with Metabolic Syndrome

Table 3

Intragroup initial and final values, change and 𝑃-values.

		M group				C group
	Initial	Final	Change	𝑃 value	Initial	Final	Change	𝑃 value
LDL (mg/dL)	111.87	108.23	−3.64	0.35	110.52	112.29	1.77	0.52
LDL (percentile)	73.67	65.77	−7.90	0.01^*	71.72	41.79	−29.93	0.85
HDL (mg/dL)	38.73	40.04	1.31	0.18	39.69	152.89	113.20	0.49
HDL (percentile)	14.33	16.30	1.97	0.41	15.52	71.07	55.55	0.77
TG (mg/dL)	182.93	151.63	−31.30	0.053	187.69	17.32	−170.37	0.02^*
TG (percentile)	91.00	86.48	−4.52	0.13	88.62	86.61	−2.01	0.15
ALT (U/L)	54.69	34.52	−20.17	0.17	38.53	23.32	−15.21	0.12
AST (U/L)	34.06	28.71	−5.35	0.43	27.60	21.91	−5.69	0.07
Weight (kg)	85.74	85.17	−0.57	0.68	78.63	82.74	4.11	0.02^*
Weight (percentile)	97.87	96.67	−1.20	0.11	97.03	95.97	−1.06	0.10
Weight (z-score)	2.43	2.20	−0.23	<0.004^*	2.21	2.03	−0.18	0.02^*
Height (cm)	162.44	165.87	3.43	<0.004^*	157.74	161.31	3.57	<0.004^*
Height (percentile)	73.13	69.80	−3.33	<0.004^*	58.60	53.13	−5.47	<0.004^*
Height (z-score)	0.83	0.69	−0.14	<0.004^*	0.28	0.12	−0.16	<0.004^*
Insulin (𝜇U/mL)	26.14	21.11	−5.03	0.22	19.63	17.26	−2.37	0.13
Glucose (mg/dL)	92.10	86.40	−5.70	0.02^*	87.50	86.94	−0.56	0.70
BP-systolic (mmHg)	125.77	120.87	−4.90	0.04^*	115.20	120.17	4.97	0.050^*
BP-diastolic (mmHg)	71.07	69.70	−1.37	0.49	72.83	72.80	−0.03	0.99
BP-systolic (percentile)	74.40	70.57	−3.83	0.47	65.63	65.30	−0.33	0.95
BP-diastolic (percentile)	57.13	57.30	0.17	0.96	65.93	61.17	−4.76	0.32
Waist (in.)	42.10	41.30	−0.80	0.62	40.21	39.63	−0.58	0.37
Waist (percentile)	89.50	88.45	−1.05	0.29	89.50	88.00	−1.50	0.08
Body fat (%)	34.95	33.14	−1.81	0.26	34.41	32.48	−1.93	0.03^*
BMI (kg/m^2)	32.07	31.07	−1.00	0.44	30.78	33.64	2.86	<0.004^*
BMI (percentile)	97.60	95.87	−1.73	0.04^*	97.47	96.90	−0.57	0.26
BMI (z-score)	2.23	2.04	−0.19	<0.004^*	2.17	2.06	−0.11	0.08

^*Reaches statistical significance (𝑃 value <0.05).