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Cholesterol
Volume 2014, Article ID 109263, 9 pages
http://dx.doi.org/10.1155/2014/109263
Review Article

Severe/Extreme Hypertriglyceridemia and LDL Apheretic Treatment: Review of the Literature, Original Findings

1Cardiology Department, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece
2Molecular Immunology Laboratory, Onassis Cardiac Surgery Center, 356 Sygrou Avenue, 176 74 Athens, Greece

Received 30 July 2014; Revised 12 November 2014; Accepted 12 November 2014; Published 16 December 2014

Academic Editor: Shinichi Oikawa

Copyright © 2014 Olga Diakoumakou et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

Hypertriglyceridemia (HTG) is a feature of numerous metabolic disorders including dyslipidemias, metabolic syndrome, and diabetes mellitus type 2 and can increase the risk of premature coronary artery disease. HTG may also be due to genetic factors (called primary HTG) and particularly the severe/extreme HTG (SEHTG), which is a usually rare genetic disorder. Even rarer are secondary cases of SEHTG caused by autoimmune disease. This review considers the causes of SEHTG, and their management including treatment with low density lipoprotein apheresis and analyzes the original findings.