A Comprehensive In Silico Analysis of the Functional and Structural Impact of Nonsynonymous SNPs in the ABCA1 Transporter Gene

Figure 5

Scatter plot shows the correlation between the predictions made by PolyPhen2 (-axis) and MutPred (-axis) for 233 amino acid substitutions on ABCA1. The diagonal line represents a perfect correlation (=1) between both prediction methods for every mutation. The overall correlation of the predictions made by both methods is high (0.57). The majority of mutations classified as pathogenic by PolyPhen2 with the highest score (=1) are also classified as pathogenic by MutPred but within a score range between 0.51 and 1.