Table of Contents
Cholesterol
Volume 2016, Article ID 7389864, 6 pages
http://dx.doi.org/10.1155/2016/7389864
Research Article

Evaluation of Antidiabetic and Antihyperlipidemic Effects of Peganum harmala Seeds in Diabetic Rats

1Department of Physiology, School of Medicine, Zahedan University of Medical Sciences, Zahedan 98167-43181, Iran
2Department of Clinical Biochemistry, School of Medicine, Zahedan University of Medical Sciences, Zahedan 98167-43181, Iran

Received 28 December 2015; Accepted 31 March 2016

Academic Editor: Abdelouahed Khalil

Copyright © 2016 Gholamreza Komeili et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. IDF, IDF Diabetes Atlas, International Diabetes Federation, 6th edition, 2013.
  2. WHO, “World Health Organization: diabetes,” Fact Sheet 312, 2015, http://www.who.int/mediacentre/factsheets/fs312/en/. View at Google Scholar
  3. Y. S. Choi, S. K. Lee, W. J. Bae et al., “Bariatric surgery improves the cavernosal neuronal, vasorelaxation, and contraction mechanisms for erectile dysfunction as result of amelioration of glucose homeostasis in a diabetic rat model,” PLoS ONE, vol. 9, no. 8, Article ID e104042, 2014. View at Publisher · View at Google Scholar · View at Scopus
  4. K. Carolo Dos Santos, C. Pereira Braga, P. Octavio Barbanera, F. Rodrigues Ferreira Seiva, A. Fernandes Jr., and A. A. Henrique Fernandes, “Cardiac energy metabolism and oxidative stress biomarkers in diabetic rat treated with resveratrol,” PLoS ONE, vol. 9, no. 7, Article ID e102775, 2014. View at Publisher · View at Google Scholar · View at Scopus
  5. P. Koroglu, G. E. Senturk, D. Yucel, O. B. Ozakpinar, F. Uras, and S. Arbak, “The effect of exogenous oxytocin on streptozotocin (STZ)-induced diabetic adult rat testes,” Peptides, vol. 63, pp. 47–54, 2014. View at Publisher · View at Google Scholar · View at Scopus
  6. J. Bolsinger, A. Pronczuk, R. Sambanthamurthi, and K. C. Hayes, “Anti-diabetic effects of palm fruit juice in the Nile rat (Arvicanthis niloticus),” Journal of Nutritional Science, vol. 3, article e5, 2014. View at Publisher · View at Google Scholar
  7. A. B. Singh, J. P. Chaturvedi, T. Narender, and A. K. Srivastava, “Preliminary studies on the hypoglycemic effect of Peganum harmala L. seeds ethanol extract on normal and streptozotocin induced diabetic rats,” Indian Journal of Clinical Biochemistry, vol. 23, no. 4, pp. 391–393, 2008. View at Publisher · View at Google Scholar · View at Scopus
  8. T. Herraiz, D. González, C. Ancín-Azpilicueta, V. J. Arán, and H. Guillén, “β-Carboline alkaloids in Peganum harmala and inhibition of human monoamine oxidase (MAO),” Food and Chemical Toxicology, vol. 48, no. 3, pp. 839–845, 2010. View at Publisher · View at Google Scholar · View at Scopus
  9. M. A. Berdai, S. Labib, and M. Harandou, “Peganum harmala L. Intoxication in a pregnant woman,” Case Reports in Emergency Medicine, vol. 2014, Article ID 783236, 3 pages, 2014. View at Publisher · View at Google Scholar
  10. H. Shao, X. Huang, Y. Zhang, and C. Zhang, “Main alkaloids of Peganum harmala L. and their different effects on dicot and monocot crops,” Molecules, vol. 18, no. 3, pp. 2623–2634, 2013. View at Publisher · View at Google Scholar · View at Scopus
  11. S. Bensalem, J. Soubhye, I. Aldib et al., “Inhibition of myeloperoxidase activity by the alkaloids of Peganum harmala L. (Zygophyllaceae),” Journal of Ethnopharmacology, vol. 154, no. 2, pp. 361–369, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. F. Lamchouri, A. Settaf, Y. Cherrah et al., “In vitro cell-toxicity of Peganum harmala alkaloids on cancerous cell-lines,” Fitoterapia, vol. 71, no. 1, pp. 50–54, 2000. View at Publisher · View at Google Scholar · View at Scopus
  13. A. M. Sobhani, S.-A. Ebrahimi, and M. Mahmoudian, “An in vitro evaluation of human DNA topoisomerase I inhibition by Peganum harmala L. seeds extract and its β-carboline alkaloids,” Journal of Pharmacy and Pharmaceutical Sciences, vol. 5, no. 1, pp. 19–23, 2002. View at Google Scholar · View at Scopus
  14. H. R. Monsef, A. Ghobadi, M. Iranshahi, and M. Abdollahi, “Antinociceptive effects of Peganum harmala L. alkaloid extract on mouse formalin test,” Journal of Pharmacy & Pharmaceutical Sciences, vol. 7, no. 1, pp. 65–69, 2004. View at Google Scholar
  15. V. K. Singh, V. Mishra, S. Tiwari et al., “Anti-secretory and cyto-protective effects of peganine hydrochloride isolated from the seeds of Peganum harmala on gastric ulcers,” Phytomedicine, vol. 20, no. 13, pp. 1180–1185, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. L. Zuo, Y. Du, M. Lu et al., “Atorvastatin inhibits hyperglycemia-induced expression of osteopontin in the diabetic rat kidney via the p38 MAPK pathway,” Molecular Biology Reports, vol. 41, no. 4, pp. 2551–2558, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. J. R. MacDonald, M. Oellermann, S. Rynbeck et al., “Transmural differences in respiratory capacity across the rat left ventricle in health, aging, and streptozotocin-induced diabetes mellitus: evidence that mitochondrial dysfunction begins in the subepicardium,” American Journal of Physiology—Cell Physiology, vol. 300, no. 2, pp. C246–C255, 2011. View at Publisher · View at Google Scholar · View at Scopus
  18. A. J. S. Fox, A. Bedi, X.-H. Deng et al., “Diabetes mellitus alters the mechanical properties of the native tendon in an experimental rat model,” Journal of Orthopaedic Research, vol. 29, no. 6, pp. 880–885, 2011. View at Publisher · View at Google Scholar · View at Scopus
  19. M. Karajibani, M. Hashemi, F. Montazerifar, A. Bolouri, and M. Dikshit, “The status of glutathione peroxidase, superoxide dismutase, vitamins A, C, E and malondialdehyde in patients with cardiovascular disease in Zahedan, Southeast Iran,” Journal of Nutritional Science and Vitaminology, vol. 55, no. 4, pp. 309–316, 2009. View at Publisher · View at Google Scholar · View at Scopus
  20. M. Hashemi, H. Mehrabifar, M. Daliri, and S. Ghavami, “Adenosine deaminase activity, trypsin inhibitory capacity and total antioxidant capacity in psoriasis,” Journal of the European Academy of Dermatology and Venereology, vol. 24, no. 3, pp. 329–334, 2010. View at Publisher · View at Google Scholar · View at Scopus
  21. I. F. F. Benzie and J. J. Strain, “The ferric reducing ability of plasma (FRAP) as a measure of “antioxidant power”: the FRAP assay,” Analytical Biochemistry, vol. 239, no. 1, pp. 70–76, 1996. View at Publisher · View at Google Scholar · View at Scopus
  22. M. Moloudizargari, P. Mikaili, S. Aghajanshakeri, M. H. Asghari, and J. Shayegh, “Pharmacological and therapeutic effects of Peganum harmala and its main alkaloids,” Pharmacognosy Reviews, vol. 7, no. 14, pp. 199–212, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. A. J. Tanweer, N. Chand, U. Saddique, C. A. Bailey, and R. U. Khan, “Antiparasitic effect of wild rue (Peganum harmala L.) against experimentally induced coccidiosis in broiler chicks,” Parasitology Research, vol. 113, no. 8, pp. 2951–2960, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. F. Khoshzaban, F. Ghaffarifar, and H. R. J. Koohsari, “Peganum harmala aqueous and ethanol extracts effects on lesions caused by Leishmania major (MRHO/IR/75/ER) in BALB/c mice,” Jundishapur Journal of Microbiology, vol. 7, no. 7, Article ID e10992, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. R. Zamora-Ros, C. Sacerdote, F. Ricceri et al., “Flavonoid and lignan intake in relation to bladder cancer risk in the European prospective investigation into cancer and nutrition (EPIC) study,” British Journal of Cancer, vol. 111, no. 9, pp. 1870–1880, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. A. Crozier, I. B. Jaganath, and M. N. Clifford, “Dietary phenolics: chemistry, bioavailability and effects on health,” Natural Product Reports, vol. 26, no. 8, pp. 1001–1043, 2009. View at Publisher · View at Google Scholar · View at Scopus
  27. D. Del Rio, G. Borges, and A. Crozier, “Berry flavonoids and phenolics: bioavailability and evidence of protective effects,” British Journal of Nutrition, vol. 104, supplement 3, pp. S67–S90, 2010. View at Publisher · View at Google Scholar · View at Scopus
  28. H. de Groot and U. Rauen, “Tissue injury by reactive oxygen species and the protective effects of flavonoids,” Fundamental and Clinical Pharmacology, vol. 12, no. 3, pp. 249–255, 1998. View at Publisher · View at Google Scholar · View at Scopus
  29. N. M. Wedick, A. Pan, A. Cassidy et al., “Dietary flavonoid intakes and risk of type 2 diabetes in US men and women,” American Journal of Clinical Nutrition, vol. 95, no. 4, pp. 925–933, 2012. View at Publisher · View at Google Scholar · View at Scopus
  30. C. J. Schorah, “Micronutrients, vitamins, and cancer risk,” Vitamins & Hormones, vol. 57, pp. 1–23, 1999. View at Google Scholar
  31. N. Tajuddeen, M. S. A. Sallau, A. M. U. Musa, D. J. A. Habila, and S. M. U. Yahaya, “Flavonoids with antimicrobial activity from the stem bark of Commiphora pedunculata (Kotschy & Peyr.) Engl,” Natural Product Research, vol. 28, no. 21, pp. 1915–1918, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. N. Chabir, H. Ibrahim, M. Romdhane et al., “Seeds of Peganum harmala L. chemical analysis, antimalarial and antioxidant activities, and cytotoxicity against human breast cancer cells,” Medicinal Chemistry, vol. 11, no. 1, pp. 94–101, 2015. View at Google Scholar · View at Scopus
  33. S. J. Zunino, “Type 2 diabetes and glycemic response to grapes or grape products,” Journal of Nutrition, vol. 139, no. 9, pp. 1794S–1800S, 2009. View at Publisher · View at Google Scholar · View at Scopus
  34. P. V. A. Babu, D. Liu, and E. R. Gilbert, “Recent advances in understanding the anti-diabetic actions of dietary flavonoids,” Journal of Nutritional Biochemistry, vol. 24, no. 11, pp. 1777–1789, 2013. View at Publisher · View at Google Scholar · View at Scopus
  35. H. Berrougui, M. Isabelle, M. Cloutier, M. Hmamouchi, and A. Khalil, “Protective effects of Peganum harmala L. extract, harmine and harmaline against human low-density lipoprotein oxidation,” The Journal of Pharmacy and Pharmacology, vol. 58, no. 7, pp. 967–974, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. Q. A. El-Dwairi and S. M. Banihani, “Histo-functional effects of Peganum harmala on male rat's spermatogenesis and fertility,” Neuroendocrinology Letters, vol. 28, no. 3, pp. 305–310, 2007. View at Google Scholar · View at Scopus
  37. F. Lamchouri, A. Settaf, Y. Cherrah et al., “Experimental toxicity of Peganum harmala seeds,” Annales Pharmaceutiques Francaises, vol. 60, no. 2, pp. 123–129, 2002. View at Google Scholar · View at Scopus