Identification of Quantitative Trait Loci That Determine Plasma Total-Cholesterol and Triglyceride Concentrations in DDD/Sgn and C57BL/6J Inbred Mice

Table 5

Significant and suggestive QTL for CHO identified by genome-wide scans of combined F₂ mice ().

QTL	Chr	Peak cM	95% CI	LOD	Nearest marker	High strain
Choldq1	1	79.2	77.5–82.5	64.7	Apoa2	DDD
Choldq9	3	41.8	12.8–62.8	2.5	D3Mit25	B6
Choldq4	5	47.8	17.8–72.0	2.1	D5Mit239	DDD
Choldq2	8	21.2	14.5–53.5	4.4	D8Mit191	B6
Choldq12	11	61.4	34.4–75.4	3.5	D11Mit124	DDD
	12	60.6	23.0–62.2	2.5	D12Mit141	B6
Choldq6	17	19.7	13.1–49.1	3.3	D17Mit176	B6

QTL, quantitative trait loci; CI, confidence interval; LOD, logarithm of the odds.
Sex was included as an additive covariate.
QTL symbols were assigned if they were significant or if they were suggestive but were identified as significant QTL at least once previously in different genetic crosses [9].
95% CI was defined by a 1.5-LOD decrease.
LOD scores for significant QTL are indicated in bold. The threshold LOD scores for significant and suggestive QTL were 3.5 and 2.1, respectively, for autosomes and 3.7 and 2.1, respectively, for Chr X.
High strain-derived allele was associated with higher plasma CHO.