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Advances on the Relationship between Circulating Cholesterol and Cardiovascular Disease and the Influences of Diets and Natural Products

Call for Papers

It is well known that blood lipid and lipoprotein profiles are associated with the development of cardiovascular and cerebrovascular diseases. Among the blood lipids, cholesterol has long been considered the primary risk factor. As such, maintaining blood cholesterol within a normal and healthy range becomes critical. Cholesterol-lowering drugs such as statins have been developed and used clinically to treat patients with hypercholesterolemia. Concurrently, natural products with health benefits such as functional foods and nutraceuticals have been developed and used to manage blood cholesterol, especially by subjects with a family history and moderately high blood cholesterol levels. Natural products have also become popular among those who have normal blood lipids but want to prevent potential development of hypercholesterolemia. Significant achievements have been made in the past decades in research and product development for the prevention and treatment of dyslipidemia. It is timely to reevaluate the impact of environmental factors, primary dietary components, and natural products including herbal products and their interactions with gene polymorphisms in regulating cholesterol metabolism and homeostasis. Further, it appears that dietary cholesterol is not as important in cholesterol homeostasis as previously reported due to the limited influence of dietary cholesterol on the circulating cholesterol levels. The impact of low-density lipoprotein (LDL) cholesterol particle size and number on vascular health needs further investigations. A recent finding on the relationship between high-density lipoprotein (HDL) cholesterol and cardiovascular disease has shaken the long-lasting HDL hypothesis, and it is important to revisit the relationship between HDL cholesterol and HDL functionality and the effectiveness of various HDL raising strategies in relation to cardiovascular health. The final, but not the last, concern is whether the total cholesterol, LDL cholesterol, non-HDL cholesterol levels, or the ratios of LDL cholesterol and non-HDL cholesterol to total cholesterol should be used to predict cardiovascular risk and accordingly used in clinical diagnosis and treatment. The goal of this special issue is to address these questions by pulling together the recent high original research articles as well as review articles.

Potential topics include but are not limited to the following:

  • Beneficial effect of functional foods, natural health products/nutraceuticals, and herbal products on circulating cholesterol and metabolism in the specific areas listed below
  • Relationship between different lipoprotein size and number (especially in LDL and HDL lipoprotein classes) and cardiovascular risk
  • New insights into HDL cholesterol hypothesis and HDL functionality: what has been learned from Mendelian randomization studies and HDL elevating drug trials?
  • Revisiting the effect of dietary cholesterol on blood cholesterol levels: what is the upper limit and should it be individualized?
  • Revisiting the ratios of LDL to HDL or total cholesterol as a diagnostic tool for cardiovascular risk
  • Gene polymorphism and personalized nutrition and medicine for the management of blood cholesterol

Authors can submit their manuscripts through the Manuscript Tracking System at

Submission DeadlineFriday, 23 March 2018
Publication DateAugust 2018

Papers are published upon acceptance, regardless of the Special Issue publication date.

Lead Guest Editor

  • Yanwen Wang, National Research Council Canada, Charlottetown, Canada

Guest Editors