Modeling Spike-Train Processing in the Cerebellum Granular Layer and Changes in Plasticity Reveal Single Neuron Effects in Neural Ensembles
Figure 4
Histogram showing the effect of LTP and LTD on spiking in the network built with detailed biophysical models. Under in vitro (a) like spike input via MF, the number of spikes changed from 720 to 2736 (gray bars). Control refers to the excitatory release probability, , which was set to 0.416. The presence of inhibition showed a sharp modulation, and the number of spikes seen in the network was 576 and during LTP it increased to 874 (black bars). LTD showed no spikes. Under in vivo (b), the change in number of spikes from control to LTP was 3600 to 4032 and during LTD was 2016 (gray bars). With inhibition (black bar), the number of spikes in the 1680 cell network decreased to 2304 (LTP), 2160 (control), and 864 (LTD).
