Enhanced Synaptic Connectivity in the Dentate Gyrus during Epileptiform Activity: Network Simulation
Figure 3
Comparison between simulations and experimental findings, showing the development of epileptogenesis and emergence of recurrent spontaneous seizures in models of status epilepticus. The status epilepticus, latent (or silent) period, and spontaneous seizures are depicted. (a) Event rate following kainic acid application (modified from van Puttena et al. [6]). (b) Diagrammatic representation of the periods (modified from Morimoto et al. [7]). (c) Average activity of the granule cells simulated with stimulation for inducing the status epilepticus. (d) Average activity of the granule cells simulating the status epilepticus and including change in the interneurons action from inhibitory to excitatory.
