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Computational Intelligence and Neuroscience
Volume 2015, Article ID 963293, 9 pages
Research Article

Effect of the Interindividual Variability on Computational Modeling of Transcranial Direct Current Stimulation

1Consiglio Nazionale delle Ricerche (CNR), Istituto di Elettronica e di Ingegneria dell’Informazione e delle Telecomunicazioni (IEIIT), Piazza Leonardo da Vinci 32, 20133 Milano, Italy
2Dipartimento di Elettronica, Informazione e Bioingegneria (DEIB), Politecnico di Milano, Piazza Leonardo da Vinci 32, 20133 Milano, Italy

Received 2 April 2015; Revised 24 June 2015; Accepted 8 July 2015

Academic Editor: Jens Christian Claussen

Copyright © 2015 Marta Parazzini et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Transcranial direct current stimulation (tDCS) is a neuromodulatory technique that delivers low intensity, direct current to cortical areas facilitating or inhibiting spontaneous neuronal activity. This paper investigates how normal variations in anatomy may affect the current flow through the brain. This was done by applying electromagnetic computational methods to human models of different age and gender and by comparing the electric field and current density amplitude distributions within the tissues. Results of this study showed that the general trend of the spatial distributions of the field amplitude shares some gross characteristics among the different human models for the same electrode montages. However, the physical dimension of the subject and his/her morphological and anatomical characteristics somehow influence the detailed field distributions such as the field values.