Novel Methods for Measuring Depth of Anesthesia by Quantifying Dominant Information Flow in Multichannel EEGs

Table 2

Population pharmacokinetic parameter estimates, interindividual variability, and median parameter values (2.5–97.5%) of the nonparametric bootstrap replicates of the final pharmacokinetic model of propofol.

Parameters		Estimates (RSE, %)	CV (%)	Median (2.5–97.5%)
		17.5 (6.6)	32.9	17.4 (15.3–19.8)
		96.3 (5.9)	—	96.5 (84.4–108)
		1460 (3.2)	—	1430 (1015–1500)
		1.13 (3.7)	19.4	1.15 (1.06–1.28)
		1.03 (4.6)	—	1.035 (0.944–1.13)
		0.894 (4.2)	18.1	0.878 (0.789–0.955)
		0.0912 (6.5)	—	0.091 (0.079–0.102)

A log-normal distribution of interindividual random variability was assumed. Residual random variability was modeled using constant CV error model. Nonparametric bootstrap analysis was repeated 1,000 times. RSE: relative standard error = SE/mean × 100 (%). LBM: lean body mass calculated using the Janmahasatian formula [31]. : central volume of distribution (Vd), : rapid peripheral Vd, : slow peripheral Vd, Cl: metabolic clearance, : intercompartmental clearance between central and rapid peripheral compartments, and : intercompartmental clearance between central and slow peripheral compartments.