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Computational Intelligence and Neuroscience
Volume 2018, Article ID 3094504, 7 pages
Research Article

Liraglutide Activates the Nrf2/HO-1 Antioxidant Pathway and Protects Brain Nerve Cells against Cerebral Ischemia in Diabetic Rats

1Department of Neurology, The Fifth Affiliated Hospital of Zunyi Medical College, Zhuhai 519100, China
2Department of Pharmacy, Xindu District People’s Hospital of Chengdu, Chengdu 610500, China
3Department of Emergency, The Fifth Affiliated Hospital of Zunyi Medical College, Zhuhai 519100, China
4Department of Neurology, Zhuhai People’s Hospital, Zhuhai 519100, China

Correspondence should be addressed to Jiangquan Han; moc.361@qjnahsdg

Received 21 September 2017; Revised 15 December 2017; Accepted 27 December 2017; Published 12 February 2018

Academic Editor: João Manuel R. S. Tavares

Copyright © 2018 Caihong Deng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


This study aimed to determine the effect of liraglutide pretreatment and to elucidate the mechanism of nuclear factor erythroid 2-related factor (Nrf2)/heme oxygenase-1 (HO-1) signaling after focal cerebral ischemia injury in diabetic rats model. Adult male Sprague-Dawley rats were randomly divided into the sham-operated (S) group, diabetes mellitus ischemia (DM + MCAO) group, liraglutide pretreatment normal blood glucose ischemia (NDM+MCAO+L) group, and liraglutide pretreatment diabetes ischemia (DM + MCAO + L) group. At 48 h after middle cerebral artery occlusion (MCAO), neurological deficits and infarct volume of brain were measured. Oxidative stress brain tissue was determined by superoxide dismutase (SOD) and myeloperoxidase (MPO) activities. The expression levels of Nrf2 and HO-1 of brain tissue were analyzed by western blotting. In the DM + MCAO + L group, neurological deficits scores and cerebral infarct volume seemed to decrease at 48 h after MCAO cerebral ischemia compared with those in DM + MCAO group (). In addition, the expression of Nrf2 and HO-1 increased in 48 h at liraglutide pretreatment groups after MCAO cerebral ischemia if compared with those in the DM + MCAO group (). Furthermore, the DM + MCAO + L group has no significant difference compared with the NDM + MCAO + L group (). To sum up, alleviating effects of liraglutide on diabetes complicated with cerebral ischemia injury rats would be related to Nrf2/HO-1 signaling pathway.