Estimation of the Motor Threshold for Near-Rectangular Stimuli Using the Hodgkin–Huxley Model

Figure 3

The effect of different pulse shapes on the MT (mean ± standard deviation). Strength-duration curves for (a) RMT measurement results and (b) AMT measurement results for monophasic pulses in [5, 27] (n = 10), which are compared to the simulation results of the HH model, (c) RMT measurement results for unidirectional pulses in [8] (n = 15). (d) Resting motor thresholds for RB, RU-N, and RU-R pulses in [28] (n = 13), in comparison with the modeling results. The stimulus intensity reflects the MT as a percentage of the maximum stimulator output. The maximum voltage of the cTMS device is 2800 V which is equivalent to 100% stimulus intensity. The filled red area shows the standard deviation of the mean, according to the experimental results. All estimated MT values are inside or very close to the area of the standard deviation.

(a)

(b)

(c)

(d)