Table of Contents
Chinese Journal of Biology
Volume 2014, Article ID 638142, 9 pages
Research Article

Microbiological and Toxicological Assessment of Pharmaceutical Wastewater from the Lagos Megacity, Nigeria

1Department of Microbiology, University of Lagos, Akoka-Yaba, Lagos, Nigeria
2Ecotoxicology Laboratory, Department of Zoology, University of Lagos, Akoka-Yaba, Lagos, Nigeria

Received 23 May 2014; Revised 31 August 2014; Accepted 31 August 2014; Published 28 September 2014

Academic Editor: Qiusheng Zheng

Copyright © 2014 Avemaria Ifeoma Obasi et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


We conducted a microbiological and toxicological profiling of a pharmaceutical wastewater, one of the major wastes entering the Lagos lagoon. The morphological characterization of seven bacterial isolates from the wastewater indicated that 4 of them were gram positive bacilli while 3 were cocci of both gram reactions. The bacterial isolates exhibited varying degrees of enzyme activities but most were able to hydrolyze starch to yield amylase. Only 3 of the isolates showed prospects as antibacterial agents, given their moderate inhibition to Staphylococcus xylosus relative to 8 other species tested. Overall, 81.3% of the isolates were resistant, and 3.3% were susceptible while 15.4% of the isolates showed intermediate sensitivity to the antibiotics. The assessment of antioxidant activities in liver samples of Nile tilapia, Oreochromis niloticus, exposed to sublethal concentrations of the effluents indicated some form of oxidative stress given the higher levels of lipid peroxidation product, malondialdehyde, in the exposed fishes relative to the control kept in dechlorinate tap water. But for reduced glutathione, activities of the antioxidative stress enzymes, superoxide dismutase (SOD), catalase (CAT), and glutathione-s-transferase (GST), were higher in the effluent exposed tilapia. Responses were not dose dependent and enzyme activities were often higher at day 14 compared to day 28. This relevance of the findings to water quality was discussed.