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Canadian Journal of Gastroenterology
Volume 2, Issue 4, Pages 137-139
Brief Communication

Pyoderma Gangrenosum and Autoimmune Chronic Active Hepatitis in a 17-Year-Old Female

Joanne M. Langley, Eve A. Roberts, Moshe Ipp, Ronald M. Laxer, Lionel Boxall, and M. James Phillips

Departments of Pediatrics and Pathology, The Hospital for Sick Children, Toronto, Ontario, Canada

Received 22 August 1988; Accepted 19 September 1988

Copyright © 1988 Hindawi Publishing Corporation. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


A 17-year-old girl presented with fever, icterus and painful small nodules on her face and a larger nodular lesion on the left shin. The patient had fatigue, intermittent jaundice and abdominal pain over the preceding three months. The nodular lesions ulcerated and had the typical clinical and histopathological appearance of pyoderma gangrenosum. Although there was no hepatosplenomegaly, serum aminotransferases and immunoglobulin G were elevated; antismooth muscle antibodies were detectable. Inflammatory bowel disease was not presenr. Autoimmune chronic active hepatitis and pyoderma gangrenosum are a rare association and this is the youngest patient in whom the association has been reported.